Streptomycin Sulfate CAS 3810-74-0 Raw Materials Powder

CAS: 3810-74-0

MF: C21H41N7O16S

Specification​: 99% min Streptomycin Sulfate

Sample:  Streptomycin Sulfate Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Streptomycin Sulfate Powder Usage and Synthesis:

Streptomycin Sulfate is an aminoglycoside antibiotic. Streptomycin has strong antibacterial action against mycobacterium tuberculosis, and its minimum inhibitory concentration is generally 0.5g/mL. It has antibacterial action against sensitive gram-negative bacilli (E. coli, Salmonella, Brucella, Pasteurella, etc.) and tuberculosis bacilli. It has synergistic bactericidal effect when used with penicillin. This product is bacteriostatic at lower concentration and bactericidal at higher concentration.

Streptomycin Sulfate Powder is a white or off-white powder. Streptomycin Sulfate Raw Materials is an aminoglycoside  antibiotic. Streptomycin has powerful Antibacterial effect against Mycobacterium tuberculosis,  Streptomycin Sulfate has antibacterial effect against sensitive gram-negative bacilli (such as Escherichia coli,  Salmonella, Brucella, Pasteurella,  etc.) and Mycobacterium tuberculosis. It has a synergistic bactericidal effect when used in combination with penicillin.  The product is antibacterial at lower concentration and bactericidal at higher concentration.

Pharmacokinetics of Streptomycin Sulfate Powder:

1 Streptomycin sulfate has enhanced efficacy when combined with penicillins, cephalosporins, lincomycin, and TMP.  

2 Streptomycin Sulfate with alkaline drugs (such as sodium bicarbonate, aminophylline, etc.) borax has enhanced efficacy, but also enhanced toxicity. 

3 Streptomycin sulfate with vitamin C, vitamin B with reduced efficacy, with aminoglycosides, cephalosporins, enhanced toxicity.

Streptomycin sulfate is the sulfate form of streptomycin, which is an antibiotic produced by Streptomyces griseus in the soil. Streptomycin was the first chemotherapeutic drug to be introduced with definite efficacy against tuberculosis. The product must be injected intramuscularly, so its long-term use is limited. Streptomycin is the most effective and least toxic antibiotic obtained by Streptomyces for extra-gastrointestinal application. It is a bactericidal agent, probably by its direct action on the bacterial ribosome, inhibiting protein synthesis and effect, mainly on extracellular (including intracellular) Mycobacterium tuberculosis. The combination of streptomycin sulfate and isoniazid, another highly effective bactericidal agent approved for extragastric application, can produce immediate and significant effects on susceptible bacteria, often with life-saving effects in critical situations.

Clinical Application of Streptomycin Sulfate Powder:

Streptomycin sulfate is an antibiotic. It is used for Gram-negative bacteria and Mycobacterium tuberculosis infections. It is mainly used for the treatment of tuberculosis in livestock and respiratory, digestive and urinary tract infections in livestock and poultry. It is mostly used clinically for the treatment of streptococcal disease, staphylococcal disease, cholera, mycobacteriosis, colds and respiratory diseases caused by sensitive bacteria in livestock and poultry. Streptomycin sulfate has strong antibacterial effect on Mycobacterium tuberculosis, not strong antibacterial effect on most gram-positive cocci (such as various streptococci) and mycobacteria (such as Pseudomonas aeruginosa, anaerobic bacteria), and strong antibacterial effect on many gram-negative mycobacteria,

This product is effective for all kinds of skin tuberculosis, and has the effect of inhibiting the reproduction of mycobacterium tuberculosis and toxin production. Streptomycin sulfate has antibacterial effect on most gram-positive and negative bacteria, especially on many gram-negative bacilli such as Escherichia coli, Salmonella, Bartonella, Borrelia burgdorferi, Mycobacterium pneumoniae, Mycobacterium dysenteriae, Mycobacterium avium, Mycobacterium rhinoceros, etc. It is the drug of choice against Mycobacterium tuberculosis and has strong action on Mycobacterium tuberculosis, with strong antibacterial effect at low concentration and bactericidal effect at high concentration.

It is effective against both Gram-positive and Gram-negative bacteria, but less effective than penicillin G against Gram-positive bacteria such as Streptococcus and Pneumococcus, and not effective against Rickettsia, protozoa, viruses and fungi; it is more effective against Mycobacterium tuberculosis and a variety of Gram-negative bacteria, such as Escherichia coli, Borrelia burgdorferi, Bacillus pneumoniae, Mycobacterium dysenteriae, Mycobacterium plague, etc.

It is mainly used for the treatment of pulmonary tuberculosis, bone tuberculosis, lymphatic tuberculosis, intestinal tuberculosis, tuberculous meningitis, etc. caused by Mycobacterium tuberculosis and meningitis, pneumonia, septicemia, abscess chest, pleurisy, peritonitis, etc. caused by sensitive strains, and also for urinary tract and respiratory tract infections caused by sensitive strains.