Cytisine Raw Material Cytisine Powder

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Cytisine Powder Usage and Synthesis.

Cytisine Powder, wild indigo base, gold chain flower base, belongs to the quinolizidine alkaloids, is a derivative of pyridine, is one of the main Cytisine Powder, wild indigo base, gold chain flower base, belongs to the quinolizidine alkaloids, is a derivative of pyridine, is one of the main alkaloids in the bitter bean grass, mostly distributed in the legume family, Berberidaceae plants.

Cytisine Raw Material has antiarrhythmic, anti-microbial infection, anti-ulcer, raise white blood cells and other aspects of pharmacological effects. effects.
Cytisine CAS 485-35-8 is mainly used clinically for the treatment of surgical trauma, battle wounds, reflex apnea in cases of poisoning caused by Cytisine is mainly used clinically for the treatment of surgical trauma, battle wounds, reflex apnea in cases of poisoning caused by asphyxiating agents, cyanogenic agents, anaesthetics, etc. and the failure of respiratory and cardiovascular activity in cases of infectious It is also used for the treatment of shock, deficiency and neonatal asphyxia.

Uses and functions of Cytisine Powder.

Cytisine is derived from the seeds of SophonaalopecuroidesL., S. flavescensAit., the whole grass of ThermopsislanceolataR.Br., the above-ground parts of T. alpinaLeceb. lupinvides (L.) Link. above-ground parts, Wisteria WisteriasinensisSweet seeds, Goldenrod Cytisusosmariensis (Coss.) Ball., Hawksbill SpartiumjuliceumL., Alternifolia wild cassia ThermopsisalternifoliaRegeletSchmath., Small-leaved Wild Cassia T. chinensisBenth.
Resuscitation of surgical trauma, war injuries and asphyxiating agents, cyanide poisons, narcotics and other poisoning-induced reflex apnea and failure of respiratory and cardiovascular activity in infectious diseases, as well as shock, deficiency and neonatal asphyxia.
Cytisine Powder is used for content determination/identification/pharmacological tests etc.

Cytisine Powder

Pharmacological effects:For reflex apnoea, shock and neonatal asphyxia caused by surgery and various traumas. The alkaloids also have various pharmacological effects such as anti-arrhythmic, anti-microbial, anti-ulcer and leucocyte raising effects, especially the strong anti-cancer activity of the compounds. They are used in the production of smoking cessation drugs, first aid drugs and cough suppressants.

Pharmacological Effects of Cytisine Powder.

Cytisine is an anti-arrhythmic agent. It reduces myocardial stress and conduction, slows the heart rate and inhibits myocardial contractility. It is used clinically for the treatment of tachycardia. It reduces myocardial stress, conduction and contractility, slows down the heart rate and prolongs the inactivity period. It is mainly used for ventricular tachycardia and functional palpitations. It has a contractile effect on the uterus and can also be used to induce labour and uterine bleeding. It is also used in the preparation of hibernation preparations for artificial hibernation therapy.

The effect of chrysophanes on the respiratory system is similar to that of nicotine, which can reflexively excite breathing. When 0.02mg/kg or 1.5mg/kg is injected intravenously into the femur, it has a strong respiratory excitation effect on anesthetized cats, and at the same time, the heart rate increases and the blood pressure rises sharply, and then returns to normal soon after the respiratory excitation effect disappears. It was also stronger than 5 times (0.3mg/kg) the dose of sarcosine.
2. The pressurizing effect on the cerebral circulation was produced by injecting 0.1mg/kg into the carotid artery of cats. This effect was inhibited by PgE1 or PgE2 and enhanced by anti-inflammatory pain.

Cytisine Powder

Production method of Cytisine Powder.

(1) 1 kg of seed powder is alkalinized with 10% KOH solution and then extracted by osmosis with chloroform or in a continuous extractor until complete. The extract is recovered from the chloroform, the residue is filtered with 500 ml of hydrochloric acid and the filtrate is decoloured with activated carbon and filtered. The alkaloids adsorbed on the activated charcoal were eluted with hot oxalic acid solution. The acid solution is combined, alkalized with 10% KOH solution and extracted with chloroform, the chloroform solution is concentrated after dehydration with anhydrous sodium sulphate, petroleum ether with a boiling range of 30-60°C is added to the concentrated solution, the alkaloids are precipitated in a slightly yellowish white colour and dried at 80° after filtration.

(2) The seed powder was treated with benzene and petroleum ether in turn, and the defatted powder was placed in air to remove the petroleum ether, then alkalized with 10% KOH solution and extracted with chloroform, the rest was treated with (1) method.

(3) The aqueous solution of acid after degreasing in (1) is added with Mayer's reagent, and the alkaloids are precipitated as tetraiodomercury salts. This precipitate is finely ground with water, treated with sodium sulphide to make the compound salt decompose, the alkali free, filtered off the mercury sulphide precipitate, acid aqueous solution with potassium hydroxide solution alkaline, extracted with chloroform, the rest as (1) method.

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