Rhaponticin materials Rhaponticin Powder

Related Attributes

Product details

Rhaponticin Powder Usage and Synthesis.

Rhaponticin has antibacterial, improve microcirculation, hypolipidemic, hypoglycaemic, antitumor, inhibit allergic reaction, regulate the body's immune defence system, antithrombotic and antioxidant effects. In addition, Rhaponticin and its metabolites have a variety of pharmacological activities, in which Rhaponticin may be used as a PPAR-γ agonist to lower blood glucose concentration to achieve the effect of diabetes treatment and the effect and the thiazolidinediones pyrrolidone is comparable to the effect of the drug is particularly striking, Rhaponticin is likely to become a natural product from the development of highly effective, low adverse effects of diabetes drugs.

Uses of Rhaponticin.

Rhubarb glycosides are one of the main active ingredients of rhubarb, and have a variety of pharmacological effects. One of the most important effects is the laxative effect, can promote intestinal peristalsis, increase the number of bowel movements, for constipation has a good relief effect.

In addition, rhubarb glycosides also have antibacterial and anti-inflammatory, antiviral, anti-tumour, antioxidant and other effects.

Studies have shown that rhubarb glycosides can inhibit the growth of a variety of bacteria and fungi, and also have a certain inhibitory effect on viral infections. At the same time, earth rhubarb glycosides can also inhibit the growth of tumour cells, with a certain anticancer effect.

In addition, earth rhubarb glycosides also have the effect of scavenging free radicals, antioxidant, can slow down the aging process, protect cells from oxidative damage. In conclusion, earth rhubarb glycosides have a variety of pharmacological effects, is a very valuable Chinese herbal medicine!

Pharmacological Effect of Rhaponticin.

Hypoglycaemic effect: Rhubarb extract is commonly used to weaken metabolic abnormalities such as diabetes, high blood cholesterol and platelet aggregation. It was shown that 70% ethanol extract of Rheum officinale significantly reduced blood glucose concentration in streptozotocin-induced diabetic mice.

The extract was separated by XAD-4 column chromatography and its 60%, 80%, and 100% methanol eluting fractions enhanced insulin sensitivity and inhibited α-glucose activity. The active substances, le fat stop and rhubarbic acid, were further isolated.

Among them, Lefontaine enhanced insulin-induced glucose uptake and triglyceride accumulation in 3T3-L1 adipocytes, and the effect was comparable to that of thiazolidinediones pyrrolidone, suggesting that Lefontaine may be an agonist of PPAR-γ, thus lowering blood glucose concentration to achieve the therapeutic effect of diabetes mellitus.

Antioxidant effect: 10 kinds of stilbene compounds isolated from rhubarb, including Lefontaine, have antioxidant activity, and kinetic studies show that this kind of compounds and linoleic acid compete to inhibit the active site of lipoxygenase, with IC50 value of 6.7~74.1 μL, and also have a significant scavenging effect on the ABTS+ free radicals (TEAC=1.16~4.64).

It has also been shown that leupeptin has scavenging effects on intracellular ROS, DPPH radicals and H2O2. Further investigation of the mechanism of leupeptin revealed that leupeptin prevented lung fibroblasts from oxidising V94-7 by increasing the antioxidant activity of the cells as well as adjusting the cellular signaling pathway (enhancing extracellular ERK phosphorylation and inhibiting AP-1 activity).

Base of Bulk Rhaponticin Powder.

Why choose us?

HRK Factory

About Shipping