HRK Supply Rifampicin raw Powder Rifampicin

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Rifampicin powder Usage and Synthesis.

1. Rifampicin is used in combination with other anti-tuberculosis drugs for the initial and retreatment of various types of tuberculosis, including the treatment of tuberculous meningitis.

2. Rifampicin combined with other drugs is used in the treatment of leprosy and non-tuberculous mycobacterium infection.

3. Rifampicin and vancomycin (intravenous) can be combined for severe infections caused by methicillin-resistant staphylococcus. The combination of rifampicin and erythromycin can be used for severe Legionella infections.

4. Rifampin is used for asymptomatic Neisseria meningitidis carriers to eliminate Neisseria meningitidis in nasopharynx; It is not suitable for the treatment of Neisseria meningitidis infection.

Uses of Rifampicin.

Broad-spectrum antibiotics. It has bacteriostatic or bactericidal effect on mycobacterium tuberculosis, gram-positive bacteria and some Gram-cloudy bacteria. It is mainly used for the infection of drug-resistant tuberculosis and drug-resistant Staphylococcus aureus, and has certain curative effect on leprosy. It is a broad-spectrum antibiotic, and can enter the cell, it is a full-effect bactericidal drug, strong bactericidal power is a broad-spectrum antibiotic, it has a strong bactericidal effect on Bacilli bifidus and gram-positive and negative bacteria. It has a broad-spectrum antibacterial effect as a pharmaceutical intermediate, and has good antibacterial activity against Gram-positive coccus and tuberculosis bacillus. The antibacterial spectrum is the same as that of rifampicin.

Pharmacological action of Bulk Rifampicin powder.

Antibacterial activity. The drug has obvious bactericidal effect on M. tuberculosis and some non-M. tuberculosis (including M. leprae, etc.) both inside and outside the host cell. Rifampicin has a good antibacterial effect on aerobic gram-positive bacteria, including staphylococcus enzyme producing strains and methicillin-resistant strains, Streptococcus pneumoniae, other streptococcus genera, Enterococcus genera, Listeria genera, anthrax bacillus, perfringens bacillus, diphtheria bacillus, anaerobic coccus, etc.

It also has high antibacterial activity against aerobic gram-negative bacteria such as Neisseria meningitidis, Haemophilus influenzae and Neisseria gonorrhoea. Rifampin also has a good effect on Legionella, and has an inhibitory effect on chlamydia trachomatis, venereal lymphogranuloma and pectin fever. Bacteria are cross-resistant to rifamycin antibiotics. Rifampicin binds firmly to the beta subunit of DNA-dependent RNA polymerase, inhibiting the synthesis of bacterial RNA and preventing the enzyme from linking to DNA, thus blocking the RNA transcription process and stopping the synthesis of DNA and proteins.

Product Methods of Rifampicin.

Rifampicin is a semi-synthetic derivative of rifamycin SV. Rifamycin SV was oxidized to rifamycin S, then formylated with formaldehyde and tert-butylamine to form 3-formyltert-butylamine rifamycin S, then reduced with vitamin C and condensed with 1-methyl-4-aminopiperazine to form rifampicin.

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