Nitrofurazone Raw Materials powder Nitrofurazone

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Nitrofurazone Powder Usage and Synthesis.

Furacillin is a kind of synthetic nitrofuran disinfectant for external use, which can interfere with the process of sugar metabolism and oxidase system of bacteria, so as to achieve the purpose of bacteriostasis or sterilization. The antibacterial spectrum of furacillin is wide, and it has resistance to a variety of gram-positive and negative bacteria. It can inhibit general bacteria in vitro, and can kill bacteria when the concentration is high. The effect of external rinsing or wet compress on surface infections and skin diseases is ideal, and it has been vigorously promoted in clinical practice.

Use of Nitrofurazone.

Furacillin is a synthetic antimicrobial that can treat diseases in livestock. A few years ago, it was widely used in livestock and aquaculture, and later studies found that the residues of nitrofuran drugs, "furazoline, furazolidone" and their metabolites in animal-derived foods can be passed to humans through the food chain, long-term intake will cause various diseases, carcinogenic, teratogenic and other side effects on the human body. The United States, Australia, Canada, Japan, Singapore, the European Union and other countries have explicitly prohibited the use of such drugs in the food industry, and strictly implemented the detection of nitrofuran residues in aquatic products. Furacillin is listed as a prohibited drug in China.

Pharmacological Effect of Nitrofurazone.

Furacillin can affect a variety of positive and negative bacteria, 1∶100000 ~ 1∶200000 solution has antibacterial effect on most bacteria, and the bactericidal concentration is about twice as high as the antibacterial concentration. However, for some strains, even much above the above concentration is not sensitive. For example, the effectiveness of aerogenes, Proteus, tuberculosis and diphtheria is poor, and the effectiveness of Pseudomonas aeruginosa is even worse.

Product Method of Bulk Nitrofurazone Powder.

Furacillin was obtained from furfural by nitration, esterification and hydrolysis, and then condensed with amino acid to obtain furacillin.

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