Dehydroepiandrosterone Powder CAS 53-43-0 Raw Material

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Dehydroepiandrosterone Powder Usage and Synthesis.

Dehydroepiandrosterone (DHEA for short), chemically known as 3-beta-hydroxyandrost-5-en-17-one, also known as Dehydroepiandrosterone Powder, is a cholesterol retaining Δ5,6 double bond and esterified 3-beta-hydroxysteroid. Dehydroepiandrosterone Powder is a kind of cholesterol retaining Δ5,6 double bond and esterified 3-beta-hydroxysteroid.

Dehydroepiandrosterone Powder is a kind of cholesterol retaining △5,6 double bond and can be esterified 3-β-hydroxy steroid, its molecular formula is C19H28O2, molecular weight is 288.41, melting point is 151℃～153℃, spin degree +5.5°, and the weight of the cholesterol is 288.41. spin degree +5.5°, is the human adrenal cortex reticular layer secretion of an adrenal hormone precursor material,

Dehydroepiandrosterone Raw Material has the physiological activity of regulating obesity, preventing diabetes, anticarcinogenic and viral infections, improving memory, immune response and stress response, reducing the risk of diabetes and other diseases.

Dehydroepiandrosterone Raw Material has the physiological activity of regulating obesity, preventing diabetes, anticarcinogenic and viral infections, improving memory, immune response and stress response, reducing tension, etc., and it is the manufacture of steroid hormones. Dehydroepiandrosterone Raw Material has physiological activities such as regulating obesity, preventing diabetes, anti-cancer, anti-viral infection, improving memory, immune response and stress response, and reducing tension.

It has physiological activities such as regulating obesity, preventing diabetes, anti-cancer, anti-viral infection, improving memory, immune response and stress response, and reducing tension.

Uses and functions of Dehydroepiandrosterone Powder.

• 1. Preventing and controlling obesity DHEA has a thyroid-like effect, can inhibit food and fat intake, reduce fat accumulation. Oral administration of small doses of DHEA sulfate has a certain effect on improving the quantity and distribution of body fat and lowering blood lipids. In addition, DS can act on the mitochondrial respiratory apparatus, inhibit food and fat intake, and related to DHEA against glucocorticoids, can prevent and control obesity.
• 2. Antidiabetic DHEA has the effect of improving glucose tolerance, increasing insulin level and antidiabetic effect.
• 3. Anti-cortical diseases DHEA can enhance the activity of the endocrine system, reduce the level of cortisol, resistance to various pathological processes. Systemic lupus erythematosus (SLE) patients take DHEA, the symptoms have greatly improved, indicating that DHEA treatment of SLE disease has a certain effect.DHEA can help the body to obtain cortical antibodies, plasma concentration of DHEA and a variety of cortical diseases have a great relationship with the lower the concentration, the greater the risk of disease.

• 4. Anti-cancer DHEA has a certain effect on the prevention and inhibition of tumour growth, the first clinical discovery of DHEA anticarcinogenic effect and reversal of breast cancer. Low levels of DHEA is associated with bladder cancer, stomach cancer, and is not associated with age. It has been proved that DHEA has a protective, synergistic effect when used in chemotherapy of tumours, as DHEA has an inhibitory effect on ribose 5-phosphate, DHEA acts as a cancer inhibitor by inhibiting excessive mitochondria (NADPH) and ribose 5-phosphate.DHEA inhibits the growth of pancreatic cancer cells, and the mechanism is presumed to be that DHEA inhibits pancreatic DHEA can inhibit the growth of pancreatic cancer cells.

• 5.Delaying aging effect: When people are 25-30 years old, the content of DHEA is the highest in the body, and it will gradually decline after 30 years old, the annual decline rate is about 2%, when people are 70 years old, the content of DHEA in the body has been reduced to less than 25% of the young; at the same time, the incidence of old-age diseases related to the decline of DHEA has also risen. It is believed that DHEA can restore the activity of GnRH neurons and prevent or ameliorate certain diseases related to DHEA decline by stimulating GnRH biosynthesis.
• 6. Immune response DHEA has the ability to restore impaired immune response, improve T-cell and B-cell immune function, DHEA plays an important role in improving the physiological activity of insulin-like growth factor (IGF-1), which is a potentially beneficial drug for the treatment of immune deficiency.
• 7.Effect on bone qualityDHEA itself can not directly and independently affect the growth and differentiation of human osteoblasts, but can affect the 1,25-dihydroxyvitamin D3 changes in osteoblasts to achieve the growth and differentiation of osteoblasts.The effectiveness of DHEA's effect on bone quality depends on the form of the presence of sex hormones in bone cells and their endocrine effects on osteoblasts.
• 8. Protein metabolism DHEA is a protein anabolic hormone that promotes protein synthesis. According to Marrero et al, feeding mice with DHEA (0.45%) can increase liver weight, increase hepatic mitochondria through hepatic protein induction, and restore RNA and protein synthesis.
• 9. Other aspects of DHEA on the treatment of menopausal syndrome, scleroderma, coronary heart disease, gout, psoriasis, AIDS and so on has made extensive clinical research. Studies have also found that tuberculosis cytoplasmic deformation pathogenesis and adrenocorticotropic hormone and anti-adrenocorticotropic hormone concentrations; fetal plasma concentrations of cortisol (Cortisol)/DHEA-S and the period of labour has a great relationship.

Pharmacological Effects of Dehydroepiandrosterone Powder.

It is in two crystal forms. Acicular crystals, melting point 140-141°C; leaflet-like crystals, melting point 152-153°C. It has right optical rotation. Soluble in ethanol, ether, benzene, slightly soluble in chloroform, petroleum ether. Precipitation when encountering Maodi Huang saponin.

Production method of Dehydroepiandrosterone Powder.

• 1.Intermediates of steroid hormones such as kynurenine and bis-alkynyl carbonyl ester. 
• 2.Participate in the synthesis of adrenal secretion of a variety of hormones

Produced by the decomposition of the 17 side chain of cholesterol, stigmasterol and diosgenin. White crystalline powder. Melting point 149-151℃. Soluble in benzene, ethanol, ether, insoluble in chloroform, petroleum ether.

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