Dexamethasone Sodium Phosphate Powder CAS 55203-24-2 Raw Material

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Dexamethasone Sodium Phosphate Powder Usage and Synthesis.

Dexamethasone Sodium Phosphate, chemically known as 16α-methyl-11β,17α,21-trihydroxy-9α-fluoropregnan-1,4-diene-3,20-dione-21-phosphate disodium salt, Dexamethasone Sodium Phosphate Powder is a kind of adrenocorticotropic hormone. drug class, Dexamethasone Sodium Phosphate Raw Material has anti-inflammatory, anti-allergic, anti-rheumatic, and immunosuppressive effects.

Uses and functions of Dexamethasone Sodium Phosphate Powder.

• (1) Anti-inflammatory effects: It can reduce and prevent tissue response to inflammation, thus reducing the manifestation of inflammation. It can inhibit the accumulation of inflammatory cells, including macrophages and leukocytes, at the site of inflammation, and inhibit phagocytosis, the release of lysosomes, and the synthesis and release of chemical intermediates of inflammation.
• (2) Immunosuppressive effects: including prevention or inhibition of cell-mediated immune responses, delayed Chemicalbook allergic reactions, reduction in the number of T lymphocytes, monocytes, and eosinophils, reduction in the binding capacity of immunoglobulins to cell surface receptors, and inhibition of interleukin synthesis and release, thereby reducing the conversion of T lymphocytes to lymphocytes and attenuating primary immune response Expansion. It also reduces the passage of immune complexes through the basement membrane and reduces the concentration of complement components and immunoglobulins.

Dexamethasone Sodium Phosphate Powder is an adrenocorticotropic hormone with anti-inflammatory, antitoxic, and anti-allergic effects.

Dexamethasone Sodium Phosphate Powder has anti-inflammatory, anti-toxic, anti-allergic and affects glucose metabolism.

Dexamethasone Sodium Phosphate Powder is used in inflammatory and allergic diseases, bovine ketonemia and sheep pregnancy toxaemia.

Pharmacological Effects of Dexamethasone Sodium Phosphate Powder.

Dexamethasone Sodium Phosphate, the name of a western medicine. Commonly used dosage forms include eye drops, injection, and so on. It is an adrenocorticotropic hormone. Mainly used for allergic and autoimmune inflammatory diseases. Mostly used for connective tissue disease, active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, ulcerative colitis, acute leukaemia, etc., also used for certain serious infections and poisoning, malignant lymphoma comprehensive treatment. It is used for iridocyclitis, iritis, keratitis, allergic conjunctivitis, blepharitis, dacryocystitis and so on. The drug medical insurance types are: Dexamethasone Sodium Phosphate for Injection, Dexamethasone Sodium Phosphate Injection for Medical Insurance Category A.

Production method of Dexamethasone Sodium Phosphate Powder.

Preparation method of Dexamethasone Sodium Phosphate for injection, including the following steps:

• (1), the synthesis of dexamethasone sodium phosphate: take dexamethasone acetate epoxide as the starting raw material, go through the ring-opening reaction, recrystallisation, alkali-catalyzed hydrolysis, esterification with pyrophosphoryl chloride, and neutralization and salting reaction in order to obtain dexamethasone sodium phosphate solution, and the dexamethasone sodium phosphate solution is recrystallized to obtain the dexamethasone sodium phosphate crystals again;
• Ring-opening reaction: take dexamethasone acetate epoxide as the starting material, add HF, DMF, the reaction temperature is -10 ℃, the reaction time is 3h for the ring-opening reaction to get dexamethasone acetate solution, the molar ratio of dexamethasone acetate epoxide, HF, DMF is 1:92:44;
• Said recrystallisation: adding methanol to the dexamethasone acetate solution for recrystallisation to obtain dexamethasone acetate; said alkali-catalyzed hydrolysis: adding the obtained dexamethasone acetate to Na2CO3 and methanol, the reaction temperature is 20 ℃, and the reaction time is 10min to obtain dexamethasone, and the molar ratio of dexamethasone acetate, Na2CO3, methanol is 1:4:214;
• Said pyrophosphoryl chloride esterification: the obtained dexamethasone was reacted with pyrophosphoryl chloride and THF to obtain dexamethasone phosphate, and the molar ratio of dexamethasone, pyrophosphoryl chloride and THF was 1:5:19;
• Said neutralisation salt formation reaction: the obtained dexamethasone phosphate is reacted with NaOH and methanol at a reaction temperature of 20°C and a reaction time of 1h to obtain dexamethasone sodium phosphate, and the molar ratio of dexamethasone phosphate, NaOH and methanol is 1:2:169;
• 2), the dexamethasone sodium phosphate crystals obtained in step 1) were dried and ball-milled into powder;
• 3), dexamethasone sodium phosphate and glucose, disodium hydrogen phosphate, sodium dihydrogen phosphate are uniformly mixed to form a composition, the weight ratio of dexamethasone sodium phosphate, disodium hydrogen phosphate is 1::0.01; 4), the composition mixed in step 3) is dissolved in a prescribed amount of water for injection, and then a prescribed amount of ethanol is added, and activated charcoal is added, and the composition is kept warm at 60° C. for 30 min.

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