High Quality Esculin Raw Powder

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Esculin Powder Usage and Synthesis.

Qinpi Aesculin is a coumarin-like compound extracted from the dried branch bark or dry bark of the bitter Tochigi ash tree of the family Mulleinaceae, and is the active ingredient of the traditional Chinese medicine Qinpi, which is a white crystalline powder with a slightly bitter odour at room temperature. Aesculin and its glycoside aesculetin are effective in the treatment of bacterial dysentery and bronchitis. In addition Qinpi Aesculetin also has anti-inflammatory, antibacterial, anticoagulant, analgesic and other activities, and has a significant diuretic effect on mice. It can inhibit the aldose reductase of rat eye lens, and is the growth inhibitor of Bacillus subtilis, and also has inhibitory effect on chemical to cancer.

Uses and functions of Esculin.

A bittering agent. Naringin dihydrochalcone obtained from the hydrolysis and hydrogenation of this product is a sweetener, and the sweetness is about 150 times that of sucrose. It has anti-inflammatory, antibacterial, anticoagulant and analgesic activities, and has significant diuretic effect on mice. It can inhibit the aldose reductase of rat eye lens, and is the growth inhibitor of Bacillus subtilis, meanwhile, it also has the inhibitory effect on chemical to cancer.

Pharmacological Effect of Esculin.

1. Anti-inflammatory, analgesic: rats injected intraperitoneally with 10mg/kg have inhibitory effects on keratine, dextrose, 5-hydroxytryptamine and histamine "arthritis", the intensity of inhibition was 35, 28, 20 and 8% respectively. Inhibitory effects on formaldehyde arthritis have also been reported, but the effects were weaker than those on carrageenan arthritis, and the inhibition of dextrose anhydride arthritis was also not obvious. It can inhibit the formation of granuloma in rats (cotton ball method), erythema induced by ultraviolet irradiation on the back of guinea pigs, and the increase of capillary permeability induced by histamine. It has weak analgesic effect.

2. Effects on urine volume and uric acid excretion: various routes of administration can enhance uric acid excretion in rats and rabbits, and there is no diuretic effect on normal rats, but there is a significant diuretic effect on mice.

3. Others: It has antibacterial, anticoagulant and inhibition of aldose reductase in rat eye lens.

Physicochemical Identification of Esculin Powder.

1. Chemical characterisation: take 1g of the powder, add 10mL of ethanol, reflux for 10min on a water bath and filter. Take 1mL of filtrate, add 2-3 drops of 1% ferric chloride solution, showing dark green; then add 3 drops of ammonia test solution and 6mL of water, shake well, and then show dark red colour in the light.

2. Fluorescence: Take a little of the product and immerse it in water or ethanol, the leachate shows blue fluorescence in daylight.

3. Thin-layer chromatography: take 1g of this product powder, add 10mL of ethanol, reflux on a water bath for 10min, cool, filtered, as a test solution. Another take Qinpi methylin and Qinpi ethylin control drugs, add ethanol to make each 1mL contains 5mg of mixed solution, as a control solution. Pipette 3μL of each of the above two solutions, respectively, on the same silica gel G thin layer plate, with toluene - ethyl acetate -ethanol - formic acid (3:4:2:1) as the unfolding agent, unfolding, take out, drying, and placed in the ultraviolet light (365nm) under the observation. The chromatogram of the test article showed fluorescent spots of the same colour in the corresponding positions with the chromatogram of the control article.

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