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Epigallocatechin gallate (EGCG) is the most potent active ingredient in tea polyphenols and belongs to the group of catechins.EGCG has antibacterial, antiviral, antioxidant, antiatherosclerotic, antithrombotic, antiangiogenic, anti-inflammatory and antitumour effects.
EGCG is found in green tea, but not in black tea. This is because the EGCG in black tea is converted into thearubigin.
EGCG in medicine and health care has a variety of diseases such as cancer prevention and treatment and enhance immunity and other functions; in the food industry can be used as antioxidant, bacteriostatic, preservation of freshness, deodorant; in the daily chemical products as a special function of the preservation of the agent, skin-care agents.
Uses and functions of Epigallocatechin Gallate.
Epigallocatechin gallate has antibacterial and anti-inflammatory, antioxidant and antimutagenic effects, and can also be used as a reversal agent for multidrug resistance in tumours, improving the sensitivity of cancer cells to chemotherapy, reducing toxicity to the heart, and endothelial protection, which effectively promotes vasodilatation and reduces the incidence of cardiovascular disease.
It has obvious anti-tumour effects, which can prevent tumourigenesis by inhibiting relevant signalling pathways such as nuclear transcription factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), epidermal growth factor receptor (EGFR), insulin-like growth factor (IGF), cyclooxygenase (COX)-2, etc., as well as tumour metastasis by inhibiting vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMPs), and urokinase-fibrinogen activator (UKF).
Physical and Chemical Properties of Epigallocatechin Gallate.
(1) inhibition of tumour cell invasion and metastasis; and
(2) Regulation of metabolic processes of tumour initiators.
(3) regulation of carcinogen metabolism enzymes.
(4) Inhibition of covalent binding of oncogenes and DNA.
(5) Inhibition of the process of tumour cell proliferation.
(6) Inhibition of nitrosation process.
(7) Significant antioxidant, free radical scavenging, anti-mutagenic effects, can enhance the function of the immune system, inhibit the growth of liver lipids and cholesterol, inhibit the growth of tumours, dysentery, typhoid fever, Staphylococcus aureus, and other bacteria also have a very strong inhibitory effect.
In vitro studies of Bulk Epigallocatechin Gallate Powder.
Epigallocatechingallate has potent antioxidant effects in healthy cells and reduces oxidative damage, acts as an anti-angiogenic and anti-tumour agent, and is also a modulator of tumour cell response to chemotherapy.
(-)-Epigallocatechingallate possesses a variety of anti-tumour effects, such as anti-proliferative, anti-neovascular, blocking various cancer cell transformations, cell cycle blockade and inhibition of tumour metastasis. (-)-Epigallocatechingallate exerts its antitumour effects by modulating several tumour-related cell signalling pathways (regulating the expression levels of key signalling proteins, such as nuclear factor-κB, MAPKs and activating proteins Chemicalbook-1, EGFR, IGF, COX-2), affecting the methylation of oncogenes and the binding of ligands to membrane receptors. Anti-tumour effects.
(-)-Epigallocatechingallate has immunomodulatory effects. Many types of immune cells are affected to varying degrees by (-)Epigallocatechingallate in both the innate and adaptive immune systems. Among these effects, significant effects on T cells have been repeatedly demonstrated, including T cell activation, proliferation, differentiation and cytokine production.
Studies based on animal models suffering from autoimmune diseases have reported that green tea/EGCG treatment results in improvement of the animals' condition.
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