Pharmaceutical raw material Paracetamol Powder

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Paracetamol Powder Usage and Synthesis.

Acetaminophen through the inhibition of hypothalamic thermoregulation centre prostaglandin synthesis, the role of antipyretic, the strength of its antipyretic effect is similar to aspirin, through the inhibition of the synthesis of prostaglandins in the central nervous system as well as block the impulses of the nociceptive nerve endings and the production of analgesia, the role of the weaker than aspirin, compared to aspirin, has the advantages of a small irritation, very little allergic reaction, etc., antipyretic analgesic effect with the analgesic effects of finasteride similar to the increase in the amount of the application of acetaminophen as a result of the restriction or prohibition of the use of finasteride in many countries.

Uses and functions of Paracetamol.

Paracetamol is mainly used for cold-induced fever, headache and relief of mild and moderate pain, such as arthralgia, muscle pain, neuralgia, migraine, dysmenorrhoea, cancer pain and post-operative analgesia.

It can also be used in patients who are allergic to, intolerant of or unfit for aspirin: such as chickenpox, haemophilia and other bleeding disorders (including patients on anticoagulant therapy), as well as patients with mild peptic ulcer and gastritis.

Pharmacological Effect of Paracetamol.

Paracetamol is an antipyretic and analgesic, through the inhibition of cyclooxygenase, selective inhibition of the hypothalamic thermoregulatory centre prostaglandin synthesis, resulting in peripheral vasodilatation, sweating to achieve the role of antipyretic, the strength of its antipyretic effect is similar to that of aspirin; through the inhibition of the synthesis and release of prostaglandins, etc., to raise the pain threshold and play an analgesic effect, belong to the peripheral analgesic, the role of the weaker than aspirin, the effect is effective only in mild to moderate pain. Paracetamol has no obvious anti-inflammatory effect.

Product method of  Bulk Paracetamol Powder.

Method 1: add p-aminophenol into dilute acetic acid, then add glacial acetic acid, warm up to 150 ℃ reaction 7h, add acetic anhydride, and then react for 2h, check the endpoint, qualified cooling to 25 ℃ or less, dumping filtration, washing to no acetic acid flavour, dumping dry, get the crude product.

Method 2: p-aminophenol, glacial acetic acid and acid containing more than 50% of the acid mother liquor together with distillation, evaporation of dilute acid rate of one-tenth of the total amount of distillation per hour, to be the internal temperature rises to 130 ℃ or more, sampling and checking the p-aminophenol residue is less than 2.5%, add dilute acid (content of 50% or more), cooling and crystallisation. Shake filtration, first wash with a small amount of dilute acid, and then wash with a large amount of water until the filtrate is nearly colourless, to get the crude product. The yield of method 1 is 90%.

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