Antipyretic and analgesic raw materials antipyrine Powder

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antipyrine Powder Usage and Synthesis.

Analytical reagent for nitric acid, nitrous acid and iodine. Determination of elements capable of forming complex cations (e.g. bismuth, tin, antimony and mercury). Determination of titanium by gravimetric analysis.

Uses and functions of antipyrine.

Antipyrine is an antipyretic and analgesic drug, and this type of non-steroidal anti-inflammatory drug has strong antipyretic and analgesic, anti-inflammatory and anti-rheumatic effects. However, due to serious adverse reactions, clinical applications have been increasingly reduced, some of the old varieties have gradually tended to phase out.

Tablets such as antipyrine, aminopyrine and anakinra are all phased out drugs announced in September 1982 by the Ministry of Health.

Antipyrine is an analytical reagent. It is used for the analysis of nitric acid, nitrous acid and iodine, for the determination of elements forming complex cations, and for the determination of titanium by weight analysis.

Characteristic of antipyrine.

Colourless crystal or white crystalline powder. Melting point 114°C, boiling point 319°C (98.8kPa), 211-212°C (1.33kPa), relative density 1.0747 (20/4°C), refractive index 1.5697. Soluble in benzene, ethanol, water, chloroform, slightly soluble in ether. Odourless, slightly bitter taste.

Production Method of  Bulk antipyrine Powder.

It is obtained from 1-phenyl-3-methyl pyrazolone-5 by methylation and hydrolysis. In a dry methylation tank, add pyrazolone, then add dimethyl sulfate, raise the temperature to 160 ℃, react for 6h, and boil with heated water for 2h.

This methylation reactant was put into a hydrolysis tank containing sodium hydroxide solution, and hydrolysed with stirring at 100-110℃ for 3h.

Static layering, take antipyrine oil layer in the crystallisation tank, add distilled water dilution, stirring, cooling down to below 10 ℃, precipitate crystals, shake filtration, washing, shake dry to get the crude product of antipyrine. The crude product is recrystallised with distilled water and decoloured with activated carbon to obtain the finished product.

Methylation operation can also use chloromethane or bromomethane as raw materials, such methylation reagent as a methanol solution, a slight excess of 1-naphthyl-3-methyl pyridone stirring reaction.

The methanol is then evaporated, the reaction product is dissolved in water, made slightly basic with sodium hydroxide, the antipyrine is extracted with benzene, recrystallised from benzene, and finally refined and recrystallised in water with activated carbon.

Alternatively, it was prepared by refluxing with equimolar N,N-phenylmethylhydrazine and ethyl acetoacetate heated on an oil bath at 130-160°C .

Antipyrine was extracted from the thick oily liquid with boiling water, and the crystals were obtained by evaporation to remove the water

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