Antibiotics raw material Aspirin Powder

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Aspirin Powder Usage and Synthesis.

Aspirin, also known as acetylsalicylic acid, belongs to the non-steroidal anti-inflammatory drugs, the earliest used for anti-inflammatory analgesic. Scientists later discovered that aspirin has the ability to prevent platelet aggregation to achieve anti-thrombotic effect. With the deepening of aspirin research, many new uses have been discovered, such as aspirin can reduce the mortality rate of myocardial infarction and stroke, but also reduce the risk of colorectal cancer.

Acetylsalicylic acid, also known as aspirin, has an inhibitory effect on platelet aggregation and prevents thrombosis, and is used clinically for the prevention of temporary ischaemic attacks, myocardial infarction, arterial thrombosis and atherosclerosis. In addition, it is also used to treat biliary ascariasis.

Uses of Aspirin.

Antipyretic and analgesic for fever, pain and rheumatoid arthritis, etc.

Salicylic acid and acetic acid. Slightly soluble in water, soluble in ethanol, ether, chloroform, also soluble in alkali hydroxide solution or carbonic acid solution, while decomposing. Commonly used antipyretic and analgesic.

Used for antipyretic, analgesic, anti-rheumatic, promoting excretion of uric acid in gout patients, anti-platelet aggregation and biliary roundworm treatment

It is the earliest, widest and most common antipyretic and analgesic antirheumatic drug. With antipyretic, analgesic, anti-inflammatory, anti-rheumatic and anti-platelet aggregation and other aspects of the pharmacological effects, play a rapid role in the efficacy of the drug, the efficacy of the drug is certain, overdose easy to diagnose and deal with, and seldom occur allergic reactions.

It is commonly used in cold and fever, headache, neuralgia, arthralgia, muscle pain, rheumatic fever, acute endocrine arthritis, rheumatoid arthritis and toothache.

Acetylsalicylic acid is a variety listed in the National Essential Drug Catalogue and is also an intermediate of other drugs.

Physiological Effects of Aspirin.

Acetylsalicylic acid (aspirin) is a traditional antipyretic and analgesic drug that also has antiplatelet aggregation properties. Acetylsalicylic acid (Aspirin) has antithrombotic properties in vivo and reduces the formation of obstructive thrombi in peripheral arteries.

It inhibits the platelet release response as well as the release of endogenous ADP, 5-HT, etc. Thus, inhibits the second phase aggregation of platelets without inhibiting their first phase aggregation.

The mechanism of action of acetylsalicylic acid (aspirin) is to acetylate the cyclooxygenase of platelets, thereby inhibiting the formation of intracyclic peroxides and the production of TXA2. It also acetylates platelet membrane proteins and inhibits platelet membrane enzymes, which also helps to inhibit platelet function.

Because of the inhibition of cyclooxygenase, it affects the synthesis of PGI2 in the blood vessel wall; it can also inhibit the enzyme of platelet TXA2 synthesis, such as in high doses, it is the production of both TXA2 and PGI2 is affected.

It is suitable for ischemic heart disease, after coronary artery formation operation (PTCA), after coronary artery bypass grafting, it can prevent transient cerebral ischemia, stroke, myocardial infarction, and reduce the incidence of cardiac arrhythmia.

Production methods of Bulk Aspirin Powder.

Acetylation of salicylic acid: in the reaction tank with acetic anhydride (add 0.7889 times the total amount of salicylic acid), and then add two-thirds of the amount of salicylic acid, stirring temperature, in the 81-82 ℃ reaction of 40-60kmin. cooling to 81-82 ℃ insulation reaction 2h. Check the free salicylic acid qualified, cooling to 13 ℃, precipitation of crystals, dumping filtration, washed and dried, at 65-70 ℃ airflow. Dry, get acetylsalicylic acid.

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