Dexamethasone Raw Materials Powder

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Dexamethasone Raw Powder Usage and Synthesis.

Dexamethasone (dexamethasone phosphate sodium EP impurity A) is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates the survival, growth and differentiation of T cells. Dexamethasone inhibits the induction of nitric oxide synthase.

It is mainly used as an anti-inflammatory and anti-allergic agent in rheumatoid arthritis and other collagenous diseases.

Uses and functions of Dexamethasone Powder.

(1) Oral acid-producing drugs reduce the gastrointestinal absorption of dexamethasone.

(2) Aminoglutethimide inhibits adrenocortical function, accelerating the metabolism of the drug and shortening its half-life. If glucocorticosteroids are used in combination with amiloride, hydrocortisone may be used.

(3) Dexamethasone may attenuate the effects of oral hypoglycemic agents, anticoagulants, and neuromuscular blocking agents, and the dose should be adjusted.

(4) Barbiturates, phenytoin, rifampicin will attenuate the metabolism promotion effect of dexamethasone.

(5) Dexamethasone increases the toxicity of salicylic acid.

(6) Dexamethasone acts antagonistically to vitamin A and should be avoided in combination.

Pharmacological Dexamethasone Raw Materials Powder.

Dexamethasone (DSMS), also known as flumethasone, fluoromethylprednisolone, and dexamethasone, is a synthetic adrenocorticotropic hormone. It is a glucocorticoid hormone anti-inflammatory and anti-allergic drug, and its pharmacological effects are mainly anti-inflammatory, antitoxic, anti-allergic and anti-rheumatic, and it is widely used in clinical practice.

In recent years, the European Union believes that the consumption of beef containing hormones such as oestradiol, luteinising hormone and medroxyprogesterone can disrupt the normal functions of the human endocrine, growth and development, immune system, reproductive system, etc., and may also be carcinogenic and teratogenic, and thus prohibit the use of such hormones in animals.

In addition, dexamethasone is also used as an animal growth regulator to promote animal protein synthesis and metabolism and increase meat production, and was once widely used as a livestock, poultry, use. However, through long-term laboratory research found that dexamethasone can make experimental animals cancer and gene mutation, dexamethasone and its residues on humans and animals have obvious toxic side effects, the use of high doses of dexamethasone can lead to muscle atrophy, growth inhibition and other side effects. It is also inferred that cancer and gene mutation may occur in human beings who use such drugs for a long period of time or consume livestock and poultry with such growth promoters for a long period of time. Therefore, it is prohibited to use these drugs in treatment and feed.

Production method of Dexamethasone Raw Materials.

A new process method for the production of dexamethasone 21-hydroxyl, using intermediate 21-acetate as a substrate, semi-solubilising the substrate with an appropriate amount of methanol containing 0-10% chloroform as a solvent, hydrolyzing the substrate with a base as a catalyst, neutralising the reaction with acetic acid after the reaction is complete, concentrating the reaction solution under reduced pressure to the appropriate volume, cooling down the temperature, filtering, rinsing the filter cake with water, and drying to obtain the 21-hydroxyl. This process can shorten the production cycle, improve the quality and yield of 21-hydroxy, and reduce the content of impurities in 21-hydroxy.

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