Irbesartan raw Powder CAS 138402-11-6 Irbesartan

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Irbesartan Usage and Synthesis.

Irbesartan, as a long-acting antihypertensive drug, is the first-line drug for hypertension, and in addition to treating hypertension, it has shown good efficacy for Parkinson's disease, diabetes and kidney disease.

Uses of Irbesartan.

Irbesartan is an angiotensin II receptor antagonist antihypertensive drug used for the treatment of essential hypertension and type 2 diabetes with hypertension

The disease is kidney disease.

This product can inhibit angiotensin II and AT1 receptor binding, inhibit vasoconstriction, reduce vascular resistance, reduce aldosterone secretion, plasma vascular tightness

The level of tensin II is increased, which plays a role in reducing blood pressure.

Drug interaction of Irbesartan.

Product Method of Irbesartan.

Method 1: (fluorenyl methoxy-carbonyl amino) cyclopentane carboxylic acid (I) aminated 4-(2-phenylcyanyl) benzylamine, and the product (Ⅲ) was rehydrated to remove the protective group on N, and compound (Ⅳ) was obtained. (Ⅳ) and triethyl orthobutyrate condensation ring to obtain compound (V), and then react with sodium azide to form tetrazole, to ebisartan.

Method 2:1 -(fluorenyl methoxycarbonyl amino) cyclopentocarboxylic acid (I) and compound (Ⅳ) condensation, the product removes the protective group on N to obtain compound (Ⅷ), and then reacts with triethyl protovalerate to obtain the product.

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