Natural Probenecid raw Materials Powder Probenecid

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Probenecid Powder Usage and Synthesis.

(1) Hyperuricemia with chronic gouty arthritis and gouty calculus, adults, 25 mg twice a day, can be increased to 500 mg twice a day after 1 week. Take about 2500mL of water a day to prevent the formation of kidney stones, and take alkalizing urine drugs when necessary. But must :1, glomerular filtration filtration greater than 50 ~ 60mL/min; 2, no history of kidney stones or kidney stones; 3, non-acidic urine; 4, do not take salicylic acid drugs; 5, regularly test blood and urine pH, liver and kidney function and blood and urine uric acid levels; 6, Adjust the dosage according to the clinical and uric acid level, and maintain the minimum effective dose for a long time.

(2) As an adjunct to antibiotic therapy, when used with antibiotics such as penicillin, ampicillin, oxacillin, o-cloxacillin, nafcillin, etc., prosulfa can inhibit the excretion of these antibiotics, increase blood drug concentration, and can be maintained for a long time.

Uses of Probenecid.

Antigout drugs. The product is an organic acid, fat soluble, excreted from the renal tubules, and easy to be absorbed back. Therefore, in the presence of propyl sulfonate, the operation of some organic acids in the renal tubules in the body will be inhibited, reducing the excretion of other organic acids. Therefore, it is safe and effective for the treatment of chronic gout. It has no effect on the pain and inflammation of acute gout and is not suitable for acute gout.

Pharmacological action of Probenecid.

Product Method of Bulk Probenecid Powder.

P-toluenesulfonamide is oxidized to p-carboxybenzene sulfonamide by sodium dichromate, and then alkylated with bromopropane.

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