Chenodeoxycholic Acid Powder CAS 474-25-9 Raw Material

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Chenodeoxycholic Acid Powder Usage and Synthesis.

Chenodeoxycholic Acid Powder is white or off-white solid at room temperature and pressure, Chenodeoxycholic Acid CAS 474-25-9 is a bioactive molecule extracted from the bile of chickens, ducks and geese.

Chenodeoxycholic Acid Raw Material can be It is used for the prevention and treatment of cholesterol gallstones and hyperlipidemia, and is also effective against bile pigment stones and mixed stones. It is mainly used as an intermediate of ursodeoxycholic acid. It is readily decomposed by bacteria in the intestinal tract, producing metabolites with hepatotoxic properties.

Application/Function of Chenodeoxycholic Acid Powder.

Chenodeoxycholic acid is a bioactive molecule extracted from the bile of chickens, ducks and geese and is used for the prevention and treatment of cholesterol gallstones and hyperlipidemia, as well as for bile pigment stones and mixed stones. In addition, the compound can be used in organic synthesis methodology studies to examine the range of substrates for newly discovered organic reactions and has applications in basic biochemical studies.

This product is extracted from the bile of chickens, ducks and geese. It is a white or light yellow crystalline powder; bitter in taste and odorous. mp141-142°C. Soluble in ethanol, chloroform and glacial acetic acid, almost insoluble in water. It can reduce the synthesis and secretion of cholesterol, and reduce the discharge of total cholesterol in bile, thus improving the bile's ability to dissolve cholesterol and promoting the dissociation of already stoned cholesterol to achieve the litholytic effect.

The concentration of this product in the gallbladder is very high after oral administration, and it can be circulated in the liver and intestine for many times. It is readily broken down by bacteria in the intestinal tract and produces hepatotoxic metabolites.

Pharmacological Effects of Chenodeoxycholic Acid Powder

Gallstone dissolving drug. It is used for the prevention and treatment of cholesterol gallstones and hyperlipidemia, and is also effective against bile pigment stones and mixed stones. It is effective in patients with mild symptoms, good gallbladder function and no obstruction of the biliary tract. Long-term use has mild diarrhea, a few patients may have pruritus, dizziness, nausea and abdominal distension, etc. Individual patients may induce biliary colic and temporary transaminase elevation.

It is contraindicated in pregnant women, women of childbearing age, pancreatitis, cirrhosis, gastric and duodenal ulcers, hepatitis, and biliary tract obstruction. This product is a dissolving agent for cholesterol gallstones. It is mainly used for the prevention and treatment of cholesterol gallstone disease.

Production method of Chenodeoxycholic Acid Powder

The process of making deoxycholic acid from goose (chicken) bile: goose (chicken) bile is hydrolyzed by NaOH to get hydrolysis solution, then acidified by HCI to get total bile acid, degreased by degreasing gasoline and ethanol to get deoxycholic acid crude product, in ethanol and barium chloride into salt to get deoxycholic acid barium salt with ethyl acetate and HCI to get crystals, washed and dried by ethyl acetate to get deoxycholic acid. The total yield (for chicken or goose bile) was 1.92%. A bile acid synthesized from cholesterol in the liver, a and selective DD2 inhibitor.

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