Chloramphenicol Powder CAS 56-75-7 Raw Material

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Chloramphenicol Powder Usage and Synthesis.

Chloramphenicol Powder, also known as chloramphenicol, is a broad-spectrum antimicrobial agent with bacterial growth inhibition produced by Streptomyces chloroticus. Natural Chloramphenicol Powder CAS 56-75-7 is levomycin (also known as levomycin). 

Chloramphenicol inhibits Gram-negative bacteria, Gram-positive bacteria, etc. 

Chloramphenicol Raw Material can be used to treat typhoid bacillary dysentery, urinary tract infection, whooping cough, pneumonia, sepsis and other diseases. 

It is applied systemically for typhoid, paratyphoid and other Salmonella and Bacteroides fragilis infections.

Chloramphenicol, also known as chloramphenicol, is a broad-spectrum antimicrobial agent with bacterial growth inhibition produced by Streptomyces chloroticus, natural chloramphenicol is levomycin (also known as levomycin).

The synthetic product is white or slightly yellow needle-like or flaky crystal, odorless, extremely bitter, slightly soluble in water, ether and chloroform, easily soluble in methanol, alcohol, acetone or ethyl acetate, insoluble in benzene and petroleum ether.

It is stable in neutral or weakly acidic aqueous solution, but it is easy to fail in case of alkali. The synthetic product is racemic, also known as Hopomycin. Hopomycin is a mixture of the levomer of chloramphenicol and the dextromer. Because the dextro-trans is not antibacterial, the efficacy of synthomycin is only half that of the natural product.

Application/Function of Chloramphenicol Powder.

• 1, Chloramphenicol is the drug of choice for typhoid and paratyphoid fever, and can be used for typhoid and Salmonella spp. infections.
• 2, Chloramphenicol Powder is used for ampicillin-resistant H. influenzae type B meningitis or pneumococcal, meningococcal meningitis, sensitive gram-negative bacillus meningitis in patients allergic to penicillin.
• 3, Chloramphenicol Powder CAS 56-75-7 is used for otogenic brain abscess with mixed infection of aerobic and anaerobic bacteria.
• 4, Severe anaerobic bacterial infections, such as Bacteroides fragilis infections.
• 5, Chloramphenicol Raw Material can be used in combination with aminoglycosides to treat various infections caused by sensitive bacteria and other microorganisms, such as septicemia and pulmonary infections caused by H. influenzae, Salmonella spp. and other gram-negative bacilli.

• 6, Topically used for the treatment of superficial infections of the eye and ear caused by E. coli, H. influenzae, Klebsiella, Staphylococcus aureus, Streptococcus haemolyticus.
• 7、It is also effective for infections caused by Rickettsia, Mycoplasma, and so on.
• 8, Not effective against Pseudomonas aeruginosa and Serratia marcescens infections.
• 9, Chloramphenicol eye drops are used to treat eye infections caused by sensitive bacteria, such as trachoma, conjunctivitis, keratitis, blepharitis, etc.
• 10, This drug local ear drops can be used to treat external otitis, acute and chronic otitis media caused by infections of sensitive bacteria. This drug ear plugs can also be used for otitis and those who have pus after mastoid radical surgery.

Pharmacological Effects of Chloramphenicol Powder

Chloramphenicol inhibits the metabolism of phenytoin, methanesulfonylurea, chlorosulfonylurea and dicoumarol (and possibly other drugs) by hepatic microsomal enzymes, resulting in a prolonged half-life and increased serum concentrations in the body.

Increased toxicity leading to death has also been reported. On the other hand, phenobarbital, phenytoin, and rifampin (Prober, 1985) can reduce serum chloramphenicol concentrations, presumably due to the induction of hepatic enzymes by the drugs.

Therefore, care should be taken to monitor serum chloramphenicol concentrations if drugs that may affect the pharmacokinetic profile of chloramphenicol are applied concomitantly. Chloramphenicol delays the response of iron, folic acid and vitamin B12 to anemia treatment.

It can also interfere with the host's recall response to tetanus toxoid. Therefore, concomitant application of chloramphenicol with active immunizing agents is probably also to be avoided.

The antagonistic effect of chloramphenicol on the bactericidal action of penicillin has been demonstrated in vitro and in animal experiments, but its clinical significance remains unclear. Such combinations should be used only when the benefits of such treatment are proven.

Production method of Chloramphenicol Powder

A large number of studies have been conducted worldwide on the production methods of chloramphenicol, which are summarized as follows

• (1) p-Nitroacetophenone method;
• (2) Styrene method;
• (3) Cinnamyl alcohol method;
• (4) p-Nitrocinnamyl alcohol method
• (5) p-nitrobenzaldehyde method. China uses p-nitroacetophenone method, which is obtained from ethylbenzene by nitration, oxidation, bromination, salt formation, hydrolysis, acetylation, addition, reduction, decomposition, spin-off, and dichloroacetylation to obtain chloramphenicol.

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