Chlorhexidine Powder CAS 55-56-1 Raw Material

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Chlorhexidine Powder Usage and Synthesis.

Chlorhexidine Powder, also known as chlorhexidine, is a cationic surfactant with the chemical name of dichlorobenzenebiguanide hexane. 

Chlorhexidine CAS 55-56-1 has a rather strong broad-spectrum antibacterial and bactericidal effect, and is a better bactericidal disinfectant, with a stronger antibacterial effect on gram-positive and negative bacteria than benzalkonium bromide. 

Chlorhexidine Raw Material is used for gingivitis (acute necrotizing ulcerative gingivitis), oral infections after dental surgery, prevention and treatment of oral infections in patients with cancer and leukemia, stomatitis with bacterial or fungal oral infections caused by denture wear, follicular stomatitis, and plaque reduction. 

Chlorhexidine Raw Material is also It is used as a disinfectant for instruments and skin, and as a preservative for eye drops.

Application/Function of Chlorhexidine Powder.

Chlorhexidine Powder adsorbs to the permeation barrier of the bacterial plasma membrane, causing the cell contents to leak out, and is bacteriostatic at low concentrations and bactericidal at high concentrations.

It is effective even in the presence of serum, blood, etc. It is not effective against bacillus, acid-fast bacilli, fungi and viruses.

Clinically used for pre-surgical hand washing, hand soaking, skin disinfection in the surgical area; oral and throat infections, wound rinsing, instrument disinfection, and environmental disinfection in the sickroom or operating room. Cream or ointment is used for infant eczema, small area burns, scalds and impetigo; powder is used for prickly heat, eczema dermatitis erythematous stage.

Film application is used for mild burns and scalds. Chlorhexidine is combined with hydrochloric acid, acetic acid and gluconic acid to form chlorhexidine hydrochloride, chlorhexidine acetate and chlorhexidine gluconate respectively.

At present, chlorhexidine acetate is commonly used in China, but chlorhexidine gluconate is mainly used in the United States and Europe, especially in the last 10 years, international research reports on chlorhexidine have focused on chlorhexidine gluconate.

Because of its low solubility in water, chlorhexidine hydrochloride is mainly used as an ointment and coating agent, and has been largely eliminated in practice.

Pharmacological Effects of Chlorhexidine Powder

It is generally believed that chlorhexidine is bactericidal, mainly by destroying the permeation barrier on the bacterial cytoplasmic membrane (instead of the previous hypothesis that the bactericidal effect is achieved by the loss of ATPase activity), and that low concentrations can lead to partial leakage of cytoplasm, while high concentrations can cause denaturation of cytoplasm coagulation and thus bactericidal.

It is used for gingivitis (acute necrotizing ulcerative gingivitis), oral infections after dental surgery, prevention and treatment of oral infections in patients with cancer and leukemia, stomatitis with bacterial or fungal oral infections caused by denture wear, follicular stomatitis, and reduction of dental plaque. Chlorhexidine Powder is a surface-active bactericidal agent with strong broad-spectrum bactericidal and bactericidal effects, effective against both gram-positive and negative bacteria.

Precautions

• 1. Avoid contact with eyes.
• 2. It can lose its drug activity when it meets cork (plug).
• 3. Cannot be mixed with soap, alkali, tincture of iodine, potassium permanganate, mercuric oxide or washing powder, and should not be used for sterilization because of antagonistic effect with anionic surfactant.
• 4. It cannot be used for aseptic treatment of surgical instruments.
• 5. It cannot be used for disinfection of excreta and secretions such as feces and sputum because it cannot kill hepatitis B virus, Mycobacterium tuberculosis and bacillus.
• 6. Avoid using highly concentrated drugs.
• 7. It is prohibited for those who are allergic to this product, anterior tooth fillings (permanent staining) and periodontitis (can increase calculus on the gums). 10 to 18 years old patients should not use the rinse-containing medicine.
• 8. Needles and cartridges soaked with this product must be rinsed with water before doing spinal puncture.
• 9. 1% aqueous solution of chlorhexidine acetate is unstable and will precipitate a white precipitate after placement, generally the acetate of this product is used to prepare ointment, gluconate can be used to prepare solution.

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