Hrk supply Ranitidine Raw materials powder

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Ranitidine powder of Usage and Synthesis.

Ranitidine hydrochloride is suitable for the treatment of gastric and duodenal ulcers after surgery, reflux esophagitis, and Zuo-Ay syndrome, as well as for the prevention of gastrointestinal bleeding caused by stress ulcers, recurrent bleeding from hemorrhagic peptic ulcers, and inhalation of gastric acid during general anesthesia.

Uses of Ranitidine.

The long acting and powerful H2 receptor antagonist can effectively inhibit the secretion of gastric acid caused by histamine, pentagastrin and food stimulation, reduce the basic gastric acid and inhibit the activity of gastric enzyme. Its action strength is 5-8 times that of cimetidine. This product is suitable for benign gastric and twelve-fat intestinal ulcers, postoperative ulcers, reflux esophagitis and Zeu-Ayers syndrome.

Potent, long-acting histamine H2 receptor antagonist. It can effectively inhibit the gastric acid secretion caused by basic gastric acid and gastrin stimulation, and reduce the activity of gastric acid and gastric enzyme. The effect is 5-8 times stronger than cimetidine, and the maintenance time is long, and there is no adverse reaction of cimetidine on the central nervous system and gonads. For gastric and duodenal ulcer and gastric acid hypersecretion disease, reflux esophagitis.

Pharmacological action of Ranitidine.

Ranitidine hydrochloride is the hydrochloride of ranitidine, an antacid drug and an anti-ulcer drug. Its pharmacological action is the same as ranitidine, also known as ranitidine, and its chemical structure is similar to cimetidine. Ranitidine is a new H2 receptor antagonist synthesized on the basis of cimetidine, and its adverse reaction is less than cimetidine. It has high curative effect on gastric and duodenal ulcer, and has the characteristics of quick and long-term effect, can effectively inhibit the gastric acid secretion caused by histamine and pentagastrin stimulation, and reduce the activity of gastric acid and gastric enzyme. The titers of inhibiting nocturnal gastric acid secretion and 24-hour gastric acid secretion by mass ratio and molar concentration ratio were 4-9 times and 5-12 times of cimetidine, respectively.

While inhibiting the secretion of gastric acid, it can also inhibit the secretion of pepsin, without affecting the secretion of gastrin and sex hormones. Although it can bind to cytochrome P450, the affinity is 1/10 of cimetidine. Oral or gastric administration can inhibit peptic, irritable and indomethacin induced gastric ulcer in rats and histamine induced gastric and duodenal ulcer in guinea pigs, and the inhibitory effect is directly proportional to the concentration of the drug.

Product Methods of Bulk Ranitidine powder.

5 - [(dimethyl amine) methyl] - 2 - (I) and cysteine furan methanol reaction, generate 2 - [[5 - [(dimethyl amine) methyl - 2 - furan base] methyl]] and ethylamine (Ⅱ).

230g N-methyl-1-methylthio-2-nitrovinylmethylamine was dissolved in 400ml water, heated and stirred at 45-50 ℃, and 321g compound (Ⅱ) was added within 4h, and continued to stir for 3.5h after addition. Then reflux again 0.5h, cool until. At 70℃, 2L 4-methyl-2-pentanone was added. The azeotrope water was steamed under reduced pressure (34.7kPa) and then treated with 10g activated carbon at 50℃. After the activated carbon is removed by filtration, it is cooled to 10℃, the ranitidine precipitated by filtration is dried, about 380g, and the melting point is 69 ~ 70℃.

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