Tenofovir disoproxil fumarate Raw Materials powder

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Tenofovir disoproxil fumarate powder Usage and Synthesis.

Tenofovir fumarate is indicated in adult patients with CHB with evidence of viral replication and persistent elevated serum aminotransferase (ALT or AST) or active liver disease. Includes adult patients with HBeAg-positive or HBeAg-negative compensatory CHB.

Uses and functions of Tenofovir disoproxil fumarate.

Nucleotide reverse transcriptase inhibitor is a prodrug of Tenofovir (PMPA, 2), which is mainly used in the clinical treatment of human immunodeficiency virus infection.

Pharmacological action of Tenofovir disoproxil fumarate.

Tenofovir diisopropioxy methyl fumarate, tenofovir diisopropioxy methyl ester, is an ester precursor of Tenofovir and an acyclic 5' -adenosine monophosphate analogue. It has broad-spectrum antiviral effect and can inhibit HIV-1, HIV-2 reverse transcriptase and HBV polymerase, thereby inhibiting viral replication. When taken orally, TDF is hydrolyzed to Tenofovir, which is phosphorylated by cell kinases to the pharmacologically active metabolite Tenofovir diphosphate, which competes with 5' -triphosphate deoxyadenosine and participates in the synthesis of viral DNA. Upon entering the viral DNA, DNA elongation is blocked due to the lack of 3'-OH, thus inhibiting viral replication.

Product method of Bulk Tenofovir disoproxil fumarate.

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