HRK Supply Baclofen raw Materials powder

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Baclofen Powder Usage and Synthesis.

Baclofen is a spasmolytic. It inhibits both monosynaptic and polysynaptic spinal cord transmission by activating GABA-receptors and inhibiting the release of excitatory amino acids glutamate and aspartate. Therefore, it can reduce the increase of limb muscle tone caused by myelopathy, multiple sclerosis and spinal cord injury. For muscle spasms caused by diseases or injuries of the spinal cord and brain.

Uses of Baclofen.

Baclofen is a skeletal muscle relaxant and spasmodic that acts on the spine. For skeletal femoral spasm in multiple sclerosis; Spinal cord infections, degenerative muscle spasms; Traumatic and redundant muscle spasms of the spinal cord. It is currently the most effective muscle relaxant with the least side effects. Used as a skeletal muscle relaxant and sedative for the spinal cord.

Pharmacological action of Baclofen.

Product method of Bulk Baclofen Powder.

P-chlorobenzaldehyde was condensed with ethyl acetoacetate to produce p-chlorobenzene - di-ethyl acetoacetate. Heated water hydrolyzes to p-chlorophenylglutaric acid. Hydrochlorophenylglutaric anhydride is formed by dehydration cyclization of acetic anhydride. Then it is aminated by concentrated ammonia water to form a chlorophenylglutaric acid imide, and finally ring-opening and degradation to p-chlorophenylaminocasic acid. The specific operation method of the final ring opening and degradation is as follows: 42.25gβ- (p-chlorophenyl) glutaric acid imide is added to 200ml aqueous solution containing 8.32g sodium hydroxide under stirring. The mixture was heated at 50℃ for 10min, cooled to 10-15℃, then added 200ml aqueous solution containing 40.9g sodium hydroxide, after 20min, added 38.8g bromine, stirred at 20-25℃ for 8h, carefully adjusted the pH value of the reaction solution with concentrated hydrochloric acid to 7, and then precipitated fine β-(p-chlorophenyl) -γ-amino-butyric acid crystals. Then recrystallized from water, melting point 206-208℃.

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