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Product details
Cinnarizine Powder is a piperazine calcium channel blocker, belongs to the peripheral vasodilator.
Stugeron Powder is also known as cinnamonazine, cinnamon benzene piperazine, cinnamon yizine, brain yizine,
Cinchonine Raw Material is white or off-white crystalline or crystalline powder, odorless, a few tasteless.
Cinnarizine Powder has a dilating effect on vascular smooth muscle, clinically Cinchonine is mainly used for the treatment of cerebrovascular disorders and peripheral vascular diseases such as cerebral embolism and cerebral thrombosis.Stugeron Powder is a long-acting multifunctional vasoconstriction antagonist, which can dilate blood vessels, improve blood circulation and prevent vascular embrittlement.
Application/Function of Cinnarizine / Stugeron Powder.
Guilizine has a dilating effect on vascular smooth muscle, and has antagonistic effects on various vasoconstrictor substances such as 5-hydroxytryptamine, epinephrine, bradykinin and incretin, which can relieve vasospasm. Its antispasmodic effect is stronger than that of poppy bases, and the sedative effect is not obvious.
It can significantly increase cerebral blood flow, significantly improve cerebral circulation and coronary circulation, and has a longer duration of action, and has an inhibitory effect on various vasoactive substances, relieving vasospasm and preventing vascular embrittlement.
It can increase coronary blood flow and cardiac output without affecting heart rate and oxygen consumption. Intravenous injection of this product can cause a transient decrease in blood pressure, but oral administration has no such effect. In addition, it prevents vascular embrittlement and has antihistamine effects.
Clinically, Guilizine is mainly used for the treatment of cerebrovascular disorders and peripheral vascular diseases such as cerebral embolism, cerebral thrombosis, cerebral atherosclerosis, cerebral circulatory insufficiency due to hypertension, cerebral hemorrhage and subarachnoid hemorrhage recovery period, and sequelae of traumatic brain injury.
It is also effective for psychoneuropathy and coronary arteriosclerosis caused by cerebral circulation disorders. It can also be used to treat nausea, vomiting and motion sickness caused by inner ear vertigo and other vagus disorders.
It is a long-acting multifunctional vasoconstrictor antagonist that can dilate blood vessels, improve blood circulation and prevent vascular embrittlement, and can be used to treat cerebrovascular diseases, as well as headaches caused by cervical vertigo, dizziness and insomnia, memory loss, hemiplegia, numbness and weakness of limbs, and slurred speech.
Production method of Cinnarizine / Stugeron Powder
Diphenylmethylpiperazine is produced from anhydrous piperazine and bromodiphenylmethane, and then condensed with benzyl chloride. Diphenylmethane is heated under light, bromine is added dropwise and held at 130°C for 1h to obtain bromodiphenylmethane, C13H11Br, [776-74-9], melting point 45°C.
Bromodiphenylmethane was added dropwise to piperazine toluene solution, stirred at 80-90°C for 3h, and the reaction solution was washed with water after cooling, then extracted with 10% dilute hydrochloric acid, precipitated by alkalinization of the acid layer, filtered and dried to obtain diphenylmethylpiperazine.
Dissolve it in 95% ethanol, add sodium carbonate, add benzene propylene chloride at about 65 ℃ drop by drop, after the drop, heating reflux 4h, while hot filtration, filtrate placed over liquid, precipitation of crystals, filtration, to get brain Yizine crude product, refined, to get the finished product with a melting point of 117-119 ℃. In terms of diphenylmethane, the total yield was 48.2%.
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