Cocarboxylase Powder CAS 154-87-0 Raw Material

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Cocarboxylase Powder Usage and Synthesis.

Cocarboxylase Powder (TPP) is the coenzyme form of vitamin B1 (thiamine), formed by phosphorylation of vitamin B1 (thiamine). 

Cocarboxylase CAS 5786-21-0 TPP+ is a coenzyme involved in the synthesis and cleavage of carbonyl carbon (aldehydes and ketones) in glucose metabolism, especially the decarboxylation of α-ketoacids. 

Thiamine pyrophosphate causes carboxylase cleavage to release carbon dioxide through the combination of carbon atoms at the N=C active site with α-carbon atoms (carbonyl carbon atoms). 

Cocarboxylase Raw Material is white crystalline powder, which can be used for biochemical research. It is clinically used to treat arrhythmia, myocardial infarction, coma and other diseases.

Uses and functions of Cocarboxylase Powder.

Vitamin B1 (VB1), also known as thiamine, is the first water-soluble vitamin to be purified by people. Vitamin B1 is mainly present in the outer skin and germ of seeds, such as rice bran and bran, which are rich in content, and are found in yeast The content is also extremely rich.

Vitamin B1 plays an important role in maintaining normal nerve conduction and normal activity of the heart and digestive system.  When lacking, easy to suffer from beriberi or multiple neuritis and other diseases.  Our country can be used for infant food, the dosage of 4~ 8mg/kg;  The consumption amount in cereal and its products was 3.0 ~ 5.0mg/kg.  The usage amount is 1 ~ 2mg/kg in liquid and milk beverage.  This product can be fortified with thiamine nitrate. The specific dosage must be converted.

• 1. vitamin b Improve sleep quality, adjust the biological clock.
• 2. vitamin b Prevent DNA damage, reduce body peroxide content, anti-aging.
• 3. vitamin b Enhance immunity, prevent depression.
• 4. vitamin b Inhibit the activity of melanocytes, whitening.

Pharmacological Effects of Cocarboxylase Powder.

ThiaminePyrophosphate (TPP), a metabolite of vitamin B1, is a cofactor synthesized in the cytosol and is required for the maintenance of cytosolic transketolase and mitochondrial pyruvate, ketoglutarate, and branched-chain ketoacid dehydrogenase activities. TPP also prevents endogenous hyperglycemia-induced retinopathy and desflurane-induced hepatotoxicity in rats. Thiamine pyrophosphate is a white crystalline powder that can be used in biochemical studies; it is used clinically for the treatment of tardive dyskinesia, myocardial infarction, and coma.

Chemically, TPP consists of a pyrimidine ring which is connected to a thiazole ring, which is in turn connected to a pyrophosphate (diphosphate) functional group.

The part of TPP molecule that is most commonly involved in reactions is the thiazole ring, which contains nitrogen and sulfur. Thus, the thiazole ring is the "reagent portion" of the molecule. The C2 of this ring is capable of acting as an acid by donating its proton and forming a carbanion. Normally, reactions that form carbanions are highly unfavorable, but the positive charge on the tetravalent nitrogen just adjacent to the carbanion stabilizes the negative charge, making the reaction more favorable. (A compound with positive and negative charges on adjacent atoms is called an ylid or ylide, so sometimes the carbanion form of TPP is referred to as the "ylid form".

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