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Lovastatin Powder Usage and Synthesis.

Cholesterol-lowering drugs and competitive inhibitors of HMG-CoA reductase, a rate-limiting enzyme for cholesterol synthesis. mevalonate, a key compound that blocks the production of cholesterol and isoprene. This product is a substrate for Pgp and CYP3A. It increases cell resistance to anti-cancer drugs, such as doxorubicin, and induces apoptosis in myeloma cells. This product induces apoptosis in many cancer cells, in part by inhibiting Rho family GTP enzymes. It causes the cell cycle to be captured in the G1 and G2/M phases.

Uses of Lovastatin.

A novel lipid regulating drug -HMG-CoA(β-hydroxyl, β-methyl-glutarate monoacyl-CoA) reductase inhibitor. It can significantly reduce the concentration of serum total cholesterol, and is hydrolyzed to the corresponding β-hydroxy acid, 3-hydroxy-3-methylglutaryl CoA reductase after oral administration, while inhibiting cholesterol synthesis. It is clinically used for heterozygous familial hypercholesterolemia, severe and mild primary hypercholesterolemia, and can also be used as an adjuvant drug for dietary therapy to reduce high cholesterol and low density protein cholesterol levels.

For heterozygous familial, non-familial, secondary types of hyperlipidemia, that is, diabetes and nephrotic syndrome secondary hypercholesterolemia. It can reduce TC, LF, LDL-C, increase HDL-C, reduce the risk of myocardial infarction, unstable angina pectoris and the necessity of coronary angioplasty.

Pharmacological action of Lovastatin.

In addition to the significant effect of lowering blood lipids, lovastatin can also significantly improve the function of endothelial cells, promote the production of nitric oxide synthetase (eNOS), and thus increase the synthesis and release of NO, which plays a key role in maintaining normal pulmonary vascular tension and reversing hypoxa-induced pulmonary vascular contraction and vascular remodeling. In addition, lovastatin has anti-inflammatory and anti-proliferative effects, and can inhibit the proliferation of renal mesangial cells and the secretion of extracellular matrix, so as to reduce the purpose of glomerular sclerosis.

Product Method of Bulk Lovastatin Powder.

Lovastatin is obtained by fermentation. The available strains are: ①Monescusruber; ②Monescuspurpureus; ③Monescuspilosus; Aspergillusterreus; ⑤PenicilliumCitrunum. The culture medium of Monescusruber was 6% glucose, 2.5% peptone, 0.5% corn pulp and 0.5% ammonium chloride. Together with the culture medium, the strains were cultured under aerobic conditions at 28℃ for 10 days. 5L filtrate was filtered and extracted with 5LPh of 3 ethyl acetate. The extraction solution was concentrated in vacuum until dry, and the remaining solution was dissolved in 100ml benzene. The filtrate was washed twice with 100ml5% sodium carbonate aqueous solution, and then stirred with 100ml0.2mol/L sodium hydroxide solution at room temperature for 2h. The water layer was collected, adjusted to Ph=3 with 6mol/L hydrochloric acid, and extracted twice with 100ml ethyl acetate. The extracted liquid is combined and evaporated until dry, resulting in 260mg of oil. The oil was dissolved in a small amount of benzene, and the resulting crystals were recrystallized with a mixture of acetone and water to obtain 87mg of colorless lovastatin crystal, melting point 157 ~ 159℃(decomposition), [α]D23+307.6°(C=1, methanol).

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