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Levomefolate Calcium Powder is the calcium salt of L-5-methyltetrahydrofolate, which belongs to the folate family of vitamins (Vitamin B9, Folic Acid), and it is a coenzyme form of folic acid.Levomefolate Calcium Raw Materials (5-mthf), is the naturally occurring salt-forming methyl derivative form of folic acid, 5 -mthf is also known as levomethylfolate, Levomefolate Calcium CAS 151533-22-1 is the most biologically active and functional form of folic acid and is more readily absorbed than regular folic acid.
Uses and functions of Levomefolate Calcium Powder.
Folic acid deficiency reduces the ability of cells to synthesise and repair DNA and supplementation may be a more favourable approach Increased folic acid reduces homocysteine levels and supports normal cell proliferation, vascular endothelial function . Cardiovascular disease, neurological function, and especially during pregnancy supplementation with 5-MTHF has been shown to reduce the risk of developing neural tube malformations and recurrences.
Pharmacological Effects of Levomefolate Calcium Powder.
The two main metabolic pathways in which ordinary folic acid must be converted to l-type methylfolate in order to participate: the methylation process and dna synthesis, the only form of free folic acid normally present in human plasma and cells is 5-mthf.
Deficiency of folic acid is usually due to vitamin deficiencies resulting in insufficient absorption, an increased need for folic acid during pregnancy and breastfeeding, child growth, and the need to give supplements when the consumption of folic acid-rich foods does not guarantee the dosage supplied under the influence of altered absorption or metabolism, or medications.
Production method of Levomefolate Calcium Powder.
The biochemical pathway to bioactive folate involves a series of enzymatic reactions and cofactors. Absorbed folate is reduced and methylated to 5-MTHF during metabolism in intestinal mucosal cells.
This transformation is limited and does not alter the appearance of folate in the blood circulation, where the bisacodylate is subsequently converted to s-adenosylmethionine (SAMe), a methyl donor involved in a number of biochemical processes.
It also serves as a donor for nucleotide synthesis and supports biosynthesis of DNA.
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