Pharmaceutical Promethazine Hcl Raw Materials Powder

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Promethazine Hcl Raw Materials Usage and Synthesis.

Promethazine Hcl is the first tricyclic antihistamine of the phenothiazine structure to be discovered. It has antitussive properties, competitively blocking the histamine H1 receptor to produce an antihistamine effect, counteracting histamine-induced dilation of the capillaries and reducing their permeability. Therefore, it can calm the cough caused by airway irritation.

1. Skin and mucous membrane allergy: for long-term, seasonal allergic rhinitis, vasodilatory rhinitis, allergic conjunctivitis caused by contact with allergens or food, urticaria, angioneurotic oedema, allergic reactions to blood or plasma products, skin scarring. If necessary, it can be combined with epinephrine as an adjuvant to this drug.

2. Motion sickness: prevention and treatment of motion sickness, seasickness, airsickness.

3. Sedation, hypnosis: for preoperative, postoperative and obstetrics. In addition, it can also be used to reduce the fear of adults and children in a light sleep state.

4. Treatment of nausea and vomiting: It is applicable to nausea and vomiting after some anaesthesia and surgery, and is also used to prevent and control radiopathogenic or pharmacogenic nausea and vomiting.

5. Post-operative pain: it can be combined with painkillers as an adjunctive medicine.

Uses and functions of Promethazine Hcl Raw Powder.

Promethazine Hcl is indicated for various allergic diseases and vomiting during pregnancy.

Indications: Can competitively block the histamine Hl receptor and produce antihistamine effect, can counteract histamine-induced capillary dilatation, reduce its permeability, relieve bronchial smooth muscle contraction caused by wheezing, stronger and more durable than the effect of benzylhydramine hydrochloride.

Pharmacological Effects of Promethazine Hcl Powder.

Promethazine Hcl is a phenothiazine antihistamine, can also be used for antiemetic, anti-motion sickness and sedative-hypnotic.

1, antihistamine effect: and tissue release of histamine competition H1 receptor, can antagonise histamine on the gastrointestinal tract, trachea, bronchial or fine bronchial smooth muscle contraction or contracture, to relieve the spasmodic and congestive effect of histamine on bronchial smooth muscle.

2, antiemetic effect: may be related to the inhibition of the medulla oblongata emetic chemoreceptor area.

3, anti-motion sickness: may be through the central anticholinergic properties, the role of the vestibular and vomiting centre and the medullary receptors in the midbrain, mainly blocking the excitation of the vestibular nucleus area cholinergic synaptic labyrinthine impulses

4, Sedative-hypnotic effect: may be due to indirectly reduce the stress of the brainstem reticularis superior activation system.

Production method of Promethazine Hcl Raw Materials Powder.

1. The main pharmacological effect of Promethazine Hcl is to block H1 receptors in smooth muscle, capillary wall and other tissues to achieve competitive antagonism with histamine. Secondly, the drug has a central stabilising effect, which can enhance the effects of anaesthetics, hypnotics and analgesics. It can also lower body temperature and suppress vomiting.

2. Clinically, it is mainly used in various allergies, vomiting during pregnancy, motion sickness, etc., combined with aminophylline in the treatment of asthma, and can be used in the combined application of pethidine, etc., and used in artificial hibernation.

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