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Product details
chlorpromazine Hcl is a representative drug of phenothiazines. To the central nervous system, small doses have a stabilising effect, large doses of continuous use has an antipsychotic effect, the product inhibits the subthalamic thermoregulatory centre, so that the body temperature rises and falls with the ambient temperature, in conjunction with other drugs, so that the body temperature falls below the normal body temperature, metabolism is lowered, known as artificial hibernation.
It is mainly used for antipsychotic, strengthening the effect of hypnotics, anaesthetics, analgesics and anticonvulsants. It can also be used to induce artificial hibernation and as an antiemetic for vomiting and intractable eructation.
Replaces benzidine, o-biphenylamine and o-biphenylylamine in trace determinations of haemoglobin and peroxidase. anisidine and o-bianisidine.
Uses and functions of chlorpromazine Hcl Raw Powder.
1. Treatment of psychosis: It is used to control the symptoms of schizophrenia or other psychotic disorders such as excitability, nervousness, hallucinations, delusions, etc. It is less effective in treating melancholic symptoms and symptoms of rigidity.
2. Antiemetic: It is effective in almost all causes of vomiting, such as uremia, gastroenteritis, cancer, pregnancy and drug-induced vomiting. It can also be used to treat persistent eructation, but it is ineffective in motion sickness vomiting.
3. Hypothermia anaesthesia and artificial hibernation: it can prevent shock when used in hypothermia anaesthesia.
4. Combined with analgesics to treat severe pain in patients with advanced cancer.
5. Treatment of heart failure.
6. Trial in the treatment of gigantism.
Pharmacological Effects of chlorpromazine Hcl Powder.
Chlorpromazine independently down-regulated the production of various (IL-2, IFN-γ, IL-4, tumour necrosis factor, and GM-CSF) in T-cell-derived lymphokines and up-regulated IL-10 secretion in an in vivo model of acute superantigen-driven immune activation.Chlorpromazine mediated SEB-driven Chlorpromazin secretion, accompanied by an enhanced accumulation of IL-10 mRNA.Chlorpromazine protects mice, normal or adrenal glands and guinea pigs against the lethality of LPS and inhibits serum levels of tumour necrosis factor Chemicalbook. Chlorpromazine prevented lipopolysaccharide lethality when administered before 30 min of LPS induction, concurrently, or 10 min after PS induction, and was ineffective when administered after 30 min of LPS induction.
Chlorpromazine significantly inhibited LPS lethality and hepatotoxicity in LPS-sensitised mice induced by actinomycin D. Chlorpromazine protected brain tissue from synaptic transmission of hypoxia-induced irreversible loss in rats In rats, Chlorpromazine also significantly delayed the onset of hypoxia-induced diffuse depression.
Production method of chlorpromazine Hcl Raw Materials Powder.
It is obtained by condensation and salt formation of 2-chlorophenothiazine [92-39-7].
1. condensation in the reaction pot add 2-chlorophenothiazine and toluene, then add sodium hydroxide, stirring and heating reflux, remove water, at 110 ℃ dropwise addition of 1-chloro-3-dimethylaminopropane toluene solution, the reaction will be decompression recovery of toluene, that is, to obtain chloropromazine, C17H19CIN2S, [50-53-3].
2. Salt formation Chlorpromazine and isopropanol are stirred and heated to 40°C, and dry hydrogen chloride is passed to pH 4-5, then chlorpromazine hydrochloride is formed into salt.
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