Diphenhydramine Hydrochloride Materials Powder

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Diphenhydramine Hydrochloride  Raw Materials Powder Usage and Synthesis.

(1) Antihistamine effect, which can compete with histamine released from tissues for H1 receptors on effector cells, thus stopping allergic reactions;

(2) Sedative-hypnotic effect caused by inhibition of central nervous activity;

(3) Enhances the action of cough suppressants;

(4) It also has anti-dizziness and anti-tremor paralysis effects. Product Name Diphenhydramine Hydrochloride Appearance Properties White crystalline powder.

Uses and functions of Diphenhydramine Hydrochloride  Powder.

Diphenhydramine hydrochloride is mainly used for: skin and mucous membrane allergies, such as urticaria, angioneurotic oedema, allergic rhinitis, pruritis, drug rash, insect bites and contact dermatitis is also effective; the prevention and treatment of motion sickness, has a strong antiemetic effect; Parkinson's disease and extrapyramidal symptoms; sedative, hypnotic; to strengthen the effect of cough suppressant for the treatment of cough caused by colds or allergies.

Pharmacological Effects of Diphenhydramine Hydrochloride  Raw Powder.

It can eliminate all kinds of allergic symptoms, its central inhibitory effect is significant, but less than the hydrochloric acid isopropylazine, still has a sedative, anti-motion sickness and antiemetic effect, also has an anticholinergic effect, can relieve bronchial smooth muscle spasm. Used for various allergic skin diseases, such as urticaria, insect bites, also used for motion sickness, nausea, vomiting.

Production method of Diphenhydramine Hydrochloride .

1, dissociation constant (25 ℃): pKa = 8.6 (for tertiary amino acid, determined by titration) 2, in each dissolution medium solubility (37 ℃) pH1.2: 1.0g / ml or more. pH4.0: 1.0g / ml to Chemicalbook on. pH6.8: 1.0mg / ml or more. Water: 1.0mg/ml or more.

3、Stability in each dissolution medium: water: not measured. In each pH dissolution medium: slowly degraded in acidic dissolution medium. Light: slowly degraded.

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