Dopamine Hydrochloride Materials Powder

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Dopamine Hydrochloride  Raw Materials Powder Usage and Synthesis.

Dopamine Hydrochloride Powder is a pressure-raising drug and a biochemical reagent. Dopamine receptor agonist, excites the heart and increases renal blood flow, used in haemorrhagic, cardiac and infectious shock.

Dopamine hydrochloride activates adrenergic receptors in the sympathetic nervous system and dopamine receptors located in the kidney, mesentery, coronary arteries, and cerebral arteries in a dose-dependent manner.At small doses (0.5-2ug/kg per minute according to body weight), it mainly acts on dopamine receptors, causing renal and mesenteric blood vessels to dilate, renal blood flow and glomerular filtration rate to increase, urine volume and sodium excretion to increase;Small to medium dose (2-10μg/kg per minute according to body weight), can directly stimulate the β1 receptor and indirectly promote the release of norepinephrine from the storage site, produce positive stress effect on myocardium, increase myocardial contractile force and stroke volume, and eventually increase cardiac output, systolic blood pressure, pulse pressure may increase, diastolic blood pressure does not change or slightly increase.
Peripheral total resistance remained unchanged, coronary blood flow and oxygen consumption were improved.At large doses (more than 10ug/kg per minute according to body weight), the a receptor is excited, resulting in increased peripheral vascular resistance, renal vasoconstriction, and decreased renal blood flow and urine volume. Both systolic and diastolic blood pressure increase due to increased cardiac output and peripheral vascular resistance.

Uses and functions of Dopamine Hydrochloride  Powder.

Dobutamine hydrochloride can be used for various types of shock and hypotension. Including toxic shock, cardiogenic shock, haemorrhagic shock, central shock, especially for patients with renal insufficiency, reduced cardiac output, increased peripheral vascular resistance and who have been replenished with sufficient blood volume. It can also be used to treat cardiac insufficiency and acute renal insufficiency.

This product is an antihypertensive agent and a biochemical reagent. Dopamine receptor agonist, excites the heart and increases renal blood flow, used in haemorrhagic, cardiac and infectious shock.

Pharmacological Effects of Dopamine Hydrochloride Raw Powder.

Dobutamine hydrochloride is the precursor of adrenaline synthesised in vivo, with β (mainly β1 receptor) receptor agonism, but also α receptor agonism, and also promotes the release of norepinephrine. It enhances myocardial contractility, increases cardiac output, and accelerates heart rate to a lesser extent (not as pronounced as isoprenaline); excitation of alpha receptors in blood vessels of tissues such as skin and muscle leads to vasoconstriction and a decrease in blood supply; excitation of dopamine receptors in blood vessels of the viscera (kidneys, mesentery, and heart) leads to dilation and an increase in blood flow. Changes in total peripheral resistance are not significant but are beneficial in improving blood supply to vital organs in shock.

Dopamine is the precursor of norepinephrine biosynthesis, one of the central transmitters, with excitation of β-receptors, a-receptors and dopamine receptors, excitation of cardiac β-receptors can increase myocardial contractility and increase cardiac output. Excitation of dopamine receptors and α-receptors causes dilatation of renal, mesenteric, coronary and cerebral blood vessels and increased blood flow.

There is a mild contractile effect on peripheral blood vessels, elevating arterial blood pressure, the prominent role of this drug is to increase renal blood flow, glomerular filtration rate increases, thus contributing to the increase in urine output, urinary sodium excretion also increased. Clinically used for various types of shock, especially for shock with reduced cardiac contractility, renal insufficiency.

Production method of Dopamine Hydrochloride .

It is obtained by ring opening of piperyleneamine. Piperonyl ethylamine and phenol were added to the reaction pot, cooled, hydrochloric acid was added slowly, and the temperature was raised to 110°C and refluxed for 12-44 h. After the reaction reached the end point, it was slightly cooled, and water was added and stirred well. Leave to stratify and separate the phenol layer. The aqueous layer was extracted with isopropyl acetate, the extracted aqueous layer was evaporated to dryness under reduced pressure (8.0kPa), then 1/2 amount of ethanol and hydrochloric acid were added and heated to dissolve. Cooling, crystallisation, filtration, filter cake washed with ethanol, drying, to get the finished product. Yield 74%.

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