Glatiramer acetate Raw Materials Powder

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Glatiramer acetate Powder Usage and Synthesis.

Used to treat multiple sclerosis, nearly 80% of the market comes from the US.

Uses and functions of Glatiramer acetate.

Glatiramer acetateIt is a synthetic analogue of myelin basic protein and an immunomodulator for use in multiple sclerosis.Glatirameracetate displays strong and promiscuous binding to MHC molecules and therefore competes with various myelin antigens for presentation to T cells.Another aspect of Glatirameracetate's action is the potent induction of T helper cell 2 ( Th2)-specific suppressor cells migrate to the brain and cause in situ bystander suppression. functions of Glatiramer acetate.

Pharmacological Effects of Glatiramer acetate Raw Materials .

Many clinical studies have confirmed that Copaxone can effectively reduce the recurrence frequency of patients with relapsing multiple sclerosis. These studies include close monitoring of patients for recurrence after dosing, assessment of accompanying symptom improvement, and improvement of the injury site as shown by MRI. In addition, studies have evaluated the impact of Copaxone on the maintenance of physiological function in patients, and the results show that Copaxone can reduce the progression of active injury to permanent neurological damage, restore axon function and neuronal integrity, that is, Copaxone prevents further damage and deterioration of the central nervous system in patients.

Production method of Glatiramer acetate Raw Powder .

The protected Glatirol was formed by polymerization of L-alanine, L-tyrosine, L-glutamate-y-benzyl ester, L-e-trifluoroacetyl lysine n-methyl anhydride (NCA) with 1, 4-dioxane as solvent, hydrogen bromide/acetic acid as protectant and diethylamine as initiator. The acid is added to the protected glatirol formed in step 1 to remove the benzyl group to form trifluoroacetyl glatirol; 1M piperidine aqueous solution was added to the trifluoroacetyl glatirol to remove the trifluoroacetyl to form the crude Glatirol. Glatirol acetate was purified by dialysis.

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