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Calcium D-pantothenate can be used as a nutritional supplement. Except for special nutritional foods, the amount used should be less than 1 per cent (in terms of calcium) (Japanese standard). When fortifying milk powder, it is 10mg/100g. 0.02% is added to shochu and whisky to enhance the flavour. Adding 0.02% to honey prevents crystallisation in winter. Buffers the bitter taste of caffeine and saccharin.
Uses and functions of Calcium D-Pantothenate.
This product is a vitamin analogue and is a component of coenzyme A. Among the mixed spins of calcium pantothenate, only the dextrose has vitaminic activity and participates in the metabolism of proteins, fats and sugars in the body.
It is used for vitamin B deficiency and peripheral neuritis, as well as for colic after surgery. In combination with vitamin C, it is used to treat disseminated lupus erythematosus.
Lack of calcium pantothenate in the human body has the following symptoms:
(1) Growth cessation, weight loss, and sudden death.
(2) Skin and hair disorders.
(2) Skin and hair disorders. (3) Nervous system disorder.
(4) Disorders of digestive organs and liver dysfunction.
(5) Influence on antibody formation.
(6) Para-kidney disorders. The human body needs about 5mg of Calcium Pantothenate (as pantothenic acid) per day.Calcium Pantothenate is used as a nutritional supplement for food processing. The amount of calcium pantothenate used must be less than 1% (in terms of calcium), except for special nutritional foods (Japan).
When fortifying milk powder, it is 10mg/100g. 0.02% is added to shochu and whisky to enhance the flavour. Adding 0.02% to honey prevents crystallisation in winter. Buffers the bitter taste of caffeine and saccharin.
Calcium D-Pantothenate can be used as biochemical research; nutrients for tissue culture medium. Clinically used in the treatment of vitamin B deficiency, peripheral neuritis, post-surgical colic.
As a food fortifier. Can be used in infant food, the use of 15-28mg/kg; in the drink 2-4mg/kg.
Pharmacological effects of Calcium D-Pantothenate.
Pantothenic acid is a precursor of coenzyme A. It is essential for a variety of metabolic processes (including carbohydrates, proteins, and lipids), and can be involved in the synthesis of steroids, porphyrins, and acetylcholine, as well as maintaining normal epithelial function.
Product Method of Bulk Calcium D-Pantothenate Powder.
Formaldehyde and anhydrous potassium carbonate were put into the reaction pot, isobutyraldehyde was added dropwise at 14-20 ℃, and the reaction was kept warm and stirred for 3h after addition; then it was left at 14-18 ℃ for 0.5h to obtain the upper layer of 2,2-dimethyl-3-hydroxypropanal as an oil.
Dissolve 2,2-dimethyl-3-hydroxypropionaldehyde in 4 times of water, sodium cyanide in 6 times of water, calcium chloride in 2 times of water, and sequentially add the above solutions to the reaction pot; add 50% sulfuric acid solution under stirring, and react for 6h at 60～65℃, and then raise the temperature to 80～85℃ and react for 3h; concentrate under reduced pressure until thick, and add 95% of ethanol to make the inorganic salts precipitated and filtered off; the filtrate After recovering ethanol by distillation under reduced pressure, 130～145℃(1.33～2.39kPa) fraction was collected, i.e. γ-butyrolactone.
Sequentially, β-aminopropionic acid, 5/6 of methanol and lime were added to the reactor, heated to 40 ℃ and stirred to react for 2h; the reaction solution was left to stand and then the upper layer of clear water was filtered, and the solid residue in the pot was washed with 1/6 of methanol and then pressed and filtered; the filtrate was placed in another reaction pot, and γ-butyrolactone was added and stirred to dissolve, and left to react for 40h to generate calcium pantothenate at room temperature.
Add water and stir to cool to O ~ -5 ℃, and add the crystal seed stirring crystallisation 24h, filtered to get calcium pantothenate.
Put 2/3 of the amount of calcium racemic pantothenate and calcium levulinate into the reaction pot, add methanol and water heated to 40 ° C and stir to dissolve, and filtered while hot, the filtrate is cooled to 15 ° C, add a small amount of calcium levulinate crystal seed, breeding crystals for 2h; when the specific optical degree of +6 ° ~ +8 °, separated from the crystals, and a small amount of methanol washed to obtain the levulinate calcium pantothenate (still used in splitting); the remaining 1/3 of the calcium racemic pantothenate stirring and dissolved in the filtrate at 35~40°C, filtered and cooled to 15°C, added a small amount of dextro-calcium pantothenate crystal seed, and nursed the crystals for 2h; when the specific rotation degree of -0.6° to -0.8.
When the crystals were separated, and washed with a small amount of methanol and vacuum dried to obtain dextro-calcium pantothenate.
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