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What is Riboflavin 5'-Monophosphate Sodium Salt Powder?
Riboflavin 5'-Monophosphate Sodium Salt is a water-soluble, bioactive form of vitamin B2, often abbreviated as FMN or FMNa. Compared to regular riboflavin, this form is phosphorylated, meaning it can be directly utilized by the body without additional metabolic conversion steps.
This powdered supplement is highly regarded for its high solubility, excellent bioavailability, and neutral pH, making it particularly suitable for addition to various health supplement formulations, including energy supplements, multivitamin formulations, and certain health support products.
Sodium Riboflavin Phosphate is a vitamin drug. Riboflavin (vitamin B2) is an important nutrient in the body and plays a key role in energy metabolism. This drug is a precursor drug for flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are important cofactors of the flavinase family.
Flavinases catalyze many biochemical reactions, most typically redox reactions, and they are key factors in cellular respiration.FAD and FMN deliver hydrogen in the mitochondrial transport chain, generating cellular energy in the process.
Uses of Riboflavin 5'-Monophosphate Sodium Salt.
The main uses of sodium riboflavin phosphate are:1, it can promote cell development and regeneration;2, it can also promote the continued growth of hair, nails, skin;3 it can help to prevent and eliminate the inflammatory reaction of the oral cavity, tongue and lips, which is also known as oral reproductive syndrome;4 it can also help to reduce the fatigue of the eyes, and enhance the vision;5 it can affect the effect of human body on the absorption of iron.
Physiological effect of Riboflavin 5'-Monophosphate Sodium Salt.
According to the literature, after oral administration, riboflavin is absorbed mainly in the proximal small intestine, food promotes the absorption of the product, and bile salts accelerate the absorption of the product.
In the dose range of 2 to 25 mg, its bioavailability is 50 to 60%, the maximum absorption of a single oral dose is 27 mg, and the excess is excreted in the feces. Flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are less well absorbed. The drug enters the circulation via the portal vein into the liver before reaching the tissues.
Most serum riboflavin is transported by albumin or immunoglobulins and diffuses through a concentration gradient into the cell. Within the cell, riboflavin is converted to FMN by flavin kinase, and FMN is converted to FAD by FAD synthase, which is the major form of riboflavin present in tissues.
Riboflavin in excess of the body's requirements is excreted primarily from the kidneys, as are some of its metabolites. The half-life of this drug is 66 to 84 minutes for oral or intramuscular administration.
Synthesis method of Bulk Riboflavin 5'-Monophosphate Sodium Salt Powder.
The current synthesis method mainly involves phosphorylation of riboflavin with phosphorus trichloride in a mixed solvent of pyridine and acetonitrile, followed by hydrolysis of the reaction mixture and neutralization with sodium hydroxide to obtain sodium riboflavin phosphate.
There is also a synthetic method in which γ-butyrolactone is used for the reaction instead of pyridine. The products produced by the above synthesis methods have low content of sodium riboflavin phosphate, which is difficult to meet the requirements of the Chinese Pharmacopoeia, high content of riboflavin diphosphate and high content of free phosphoric acid; more impurities, low quality; and large amount of contaminated waste liquid disposal.
The main factors affecting the quality of sodium riboflavin phosphate are related substances and free phosphoric acid content, the relevant substances are riboflavin diphosphate and free riboflavin, of which riboflavin diphosphate is 3′,4′-riboflavin diphosphate, 3′,5′-riboflavin diphosphate, 4′,5′-riboflavin diphosphate and the sum of riboflavin diphosphate; Pharmacopoeia standard control limit of the content of the upper limit are 6%.
Usage Recommendations and Precautions
The standard recommended dose is usually between 25-100 mg/day, depending on individual needs and the formulation. It is recommended to take it with meals to optimize absorption. While riboflavin sodium phosphate is generally considered safe, it is always wise to consult a healthcare professional before starting any new supplement, especially for pregnant women, breastfeeding women, or those taking other medications.
Excessive intake may cause urine to appear bright yellow, which is normal and indicates that the body is excreting unused vitamin B2.
Frequently Asked Questions
Q1: What is the difference between Riboflavin 5'-Monophosphate Sodium Salt and regular riboflavin?
A1: The main difference lies in bioavailability and absorption. FMN is in its activated form and can be used directly without conversion in the body, while regular riboflavin needs to be converted into its active form in the body. This makes FMN particularly suitable for people who may have difficulty metabolizing standard vitamin B2.
Q2: What are the benefits of this supplement for athletic performance?
A2: By supporting cellular energy production (ATP synthesis), Riboflavin 5'-Monophosphate Sodium Salt can help reduce fatigue, support energy metabolism during exercise, and promote post-exercise recovery. Many athletes in Europe and America use it as part of their comprehensive nutrition program.
Q3: Is it suitable for vegetarians and vegans?
A3: Yes, high-quality Riboflavin 5'-Monophosphate Sodium Salt Powder is typically produced through a fermentation process and is suitable for vegetarian and vegan diets. Please check the certification label of the specific product before purchasing.
Q4: How can I determine the quality of a supplement?
A4: Look for brands that provide third-party testing certification, manufacture according to cGMP standards, and have transparent ingredient sourcing. In the US and Europe, certification from reputable certification bodies is also an important indicator of quality.
Q5: Are there any side effects?
A5: Side effects are rare and mild at the recommended dosage. Very high doses may cause urine to turn yellow, which is normal. As with any supplement, consult a healthcare professional if you have specific health issues or are taking medication.
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