Nicotinamide Adenine Dinucleotide Raw Material NAD Powder

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β-Nicotinamide Adenine Dinucleotide Powder Usage and Synthesis

China Nicotinamide Adenine Dinucleotide Raw Material Factory Supply Organic Parsley Leaf Capsules Raw Material, High Quality NAD Powder Purity 99% β-Nicotinamide Adenine Dinucleotide Powder is involved in a variety of physiological activities such as cellular material metabolism, energy synthesis, cellular DNA repair, and has an important role in the body's immune ability.

Manufactory Supply Nicotinamide Adenine Dinucleotide Raw Material, High Purity Nicotinamide Adenine Dinucleotide Powder, High Quality NAD+ Powder.

Uses and functions of β-Nicotinamide Adenine Dinucleotide Powder

Nicotinamide adenine dinucleotide (abbreviated NAD), also known as pyridine diphosphate nucleotide (abbreviated DPN), or co-dehydrogenase I or coenzyme I.

Both oxidised (NAD+) and reduced (NADH) states exist in mammals. The oxidised form (NAD+) has a maximum ultraviolet absorption spectrum at 260 nm, and is transformed into the reduced form (NADH) by various deaminases, which accept a hydrogen atom and an electron from the substrate, and has a maximum absorption at 340 nm.

Beta-nicotinamide adenine dinucleotide is used as a coenzyme in redox reactions, as a donor of the ribose portion of ADP in ADP ribosylation reactions, and as a precursor of the second messenger molecule, cyclic ADP ribose.

Beta-nicotinamide adenine dinucleotide also serves as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins, which use NAD+ to remove acetyl groups from proteins.

Pharmacological Effects of Nicotinamide Adenine Dinucleotide Raw Material

Nicotinamide adenine dinucleotide is involved in a variety of physiological activities such as cellular material metabolism, energy synthesis, cellular DNA repair, and plays an important role in the body's immune ability.

In a healthy state, the concentration of nicotinamide adenine dinucleotide in the body is stable, maintaining the normal function of the cells.

The concentration of nicotinamide adenine dinucleotide in the body determines the process and degree of cellular aging, and a decrease in concentration accelerates the process of cellular aging.

Studies have shown that NAD+ has a protective effect on ischemic surgery-induced renal infarction, significantly reducing serum urea nitrogen and creatinine levels;

NAD+ has a protective effect on renal tubular injury induced by ischaemic surgery.

Production method of NAD+ Powder

CN201511022464.3 presents a method for preparing nicotinamide adenine dinucleotide, comprising the following steps:

• S1, breaking cells: yeast cells are added to an aqueous hydrochloric acid solution and soaked for 0.5-2.5h, and after temperature difference wall-breaking treatment, the cells are filtered with a ceramic membrane, and the filtrate is taken to obtain the clear liquid A;
• S2, concentration: take the clear liquid A obtained in S1 and ultrafiltration, take the ultrafiltration solution and nanofiltration to obtain the concentrate B, and adjust the pH of the concentrate B with aqueous hydrochloric acid solution = 2-2.5 to obtain the concentrate C;
• S3, elution: the concentrated solution C obtained in S2 was passed through a D152 resin column, eluted with ammonia, and the eluent D was collected, and the pH of the eluent D was adjusted with an aqueous hydrochloric acid solution = 7-8, then it was passed through a 717 resin column, and eluted with an aqueous potassium chloride solution, and the synthesised solution E was collected;
• S4, separation: nanofiltration of the synthesised liquid E obtained in S3 to obtain the concentrate F; adjusting the pH of the concentrate F = 1-3 with aqueous nitric acid, adding acetone to precipitate, and centrifugation to obtain the solid G;
• S5, purification: the solid G obtained in S4 was dissolved with water, over the preparative chromatography, desalination, separation, collection of the isolate, concentration, lyophilization to obtain nicotinamide adenine dinucleotide.

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