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Metronidazole Usage and Function.

Metronidazole can kill the anaerobic bacteria that cause oral infection. In 1978, Metronidazole was identified by the World Health Organization as a special drug against anaerobic bacterial infection, and it is widely used in the prevention and treatment of oral anaerobic bacterial infection. In the hospital, this product is often used to prevent and treat respiratory tract, digestive tract, abdominal cavity and pelvic infection, skin soft tissue and bone and joint infection, pericarditis, sepsis and brain treatment caused by anaerobic bacteria.

Uses of Metronidazole.

Anti-vaginal trichomonas. Metronidazole is currently the world's treatment of trichomonas vaginitis specific drug, oral 10mg/kg can treat vaginal trichomonas, but will not affect the growth of normal vaginal flora.

Resist amoebic infection. Metronidazole can be used to treat both intestinal and external amebiasis, and it is the first choice for anti-amebiasis infection.

Prevent infection after surgery. Prophylactic use of metronidazole before and after reoperation can significantly reduce the rate of wound infection. It is mainly suitable for anti-infection of appendectomy, rectocolon surgery, abdominal infection, etc.

Treatment of peptic ulcer. Metronidazole can protect mucous membrane and promote mucous membrane regeneration. Gastric and duodenal ulcer using metronidazole 1g/ day, divided into 3 times, can achieve the ideal cure rate and ulcer healing rate.

Treatment of persistent cough with abscess caused by bronchopneumonia infection. Metronidazole can quickly control infection and improve symptoms.

Hyperlipidemia Metronidazole has a significant effect on lowering blood lipids, 3 times a day, 0.2-0.4g each time, for 4 weeks.

Treat tetanus. It is reported that metronidazole has a very good therapeutic effect on tetanus, even higher than penicillin. The application of metronidazole was accompanied by debridement, antitoxin injection and intravenous fluid rehydration. Admitted 1.6-2.6g daily, divided into 3-4 oral; Children should take 50mg per kilogram daily for 1-2 consecutive courses.

Oral diseases. Periodontitis, gingivitis, periodontal abscess, upper frontal sinusitis, tonsillitis, etc. The dosage is 0.2-0.8g 3 times a day for one week.

Pharmacological action of Metronidazole.

The nitro of metronidazole is reduced to cytotoxic active products by anaerobic bacteria in an anaerobic environment, which inhibits the DNA synthesis of sensitive bacteria, causes the death of bacteria and shows anti-anaerobic effect. It has a strong antibacterial effect on most anaerobic bacteria, but is ineffective against aerobic bacteria and facultative anaerobic bacteria. It is mainly used for the prevention and treatment of anaerobic bacteria caused by infection, such as respiratory tract, digestive tract, abdominal cavity and basin pus infection, skin soft tissue, bone and bone joint infection and endocarditis, septicemia and meningitis caused by Bacteroides fragile, in addition, it is also widely used in the prevention and treatment of oral anaerobic bacteria infection.

Product Method of Bulk Metronidazole Powder.

It is prepared by the addition of 2-methyl-5-nitroimidazole (see 25010) to ethylene oxide. Dissolve 2-methyl-5-nitroimidazole in formic acid, add ethylene oxide successively at 30-40 ° C, and add sulfuric acid in the middle of the feed. Gabi, reaction 1h. Recover formic acid under reduced pressure, dissolve with water, cool to 10℃, and filter. The filtrate was adjusted to pH=10 with sodium hydroxide solution, then placed for cooling, filtration, and water washing to near-medium reconstruction. Recrystallize with water. The activated carbon is decolorized, and metronidazole is obtained.

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