Colistin Sulphate Powder CAS 1264-72-8 Raw Material

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Colistin Sulphate Powder Usage and Synthesis.

Colistin Sulphate Powder, also known as Colistin, Polymyxin E, Anti-Enemy, etc., is a white or almost white powder, odorless, bitter in taste with It is a white or almost white powder, odorless, bitter in taste with moisture-attracting properties, easily soluble in water. 

colistin Sulphate CAS 1264-72-8 is produced by Polymyxin, which has a strong antibacterial effect on Colistin Sulphate Raw Material is used for the treatment of intestinal diseases caused by Gram-negative bacteria, Colistin Sulphate Raw Material is used as feed additive and has obvious growth The raw material is used as feed additive and has obvious growth promoting effect.

Uses and functions of Colistin Sulphate Powder.

• (1) It has strong anti-Gram-negative bacillus ability. Especially, it has specific developmental hindering effect on E. coli, Salmonella and Pseudomonas aeruginosa.
• (2) It has bactericidal effect. By impeding the selective permeability function of cell membrane, it causes bacterial death
• (3) There is almost no problem of drug resistance. No R-factor resistance was found.
• (4) Synergistic effect with anti-Gram-positive drugs. Combined with bacteriophage zinc, flavomycin, sulfonamides, semi-synthetic penicillin, gentamicin, etc., its effect is even better.
• (5) No residue. When administered orally, it is almost not absorbed by the intestine, but when injected intramuscularly, the blood is well absorbed, so there is no need to worry about residues in livestock products.
• (6) Promote the growth of livestock and poultry, prevent and control infectious enteritis of livestock and poultry, etc.

Pharmacological Effects of Colistin Sulphate Powder.

The main reason for the bactericidal activity of Colistin Sulphate is that there are three key active groups in its molecular structure: fatty acid, positively charged amino acid and cyclic peptide. The absence or alteration of any of these structures will significantly reduce the bactericidal activity. The bactericidal effect of mucilage sulfate is mainly due to the positively charged free amino acid, which can bind to the negatively charged phosphate in the phospholipid of the cytoplasmic membrane of bacterial cells, causing the surface tension of the cytoplasmic membrane of bacteria to decrease, and destroying the integrity of the cell membrane, increasing the permeability of the cell membrane, and causing the main components of the cell, especially purines and pyrimidines, to flow out from the cytoplasm, thus causing the inhibition of bacterial growth or causing bacterial death.

Since the cell membrane of Gram-negative bacteria contains more phospholipids, while the cell membrane of Gram-positive bacteria contains very little phospholipids, the antibacterial effect of mucilage sulfate is mainly strongest for Gram-negative bacteria. In view of this, the antibacterial spectrum of mucilage sulfate is also limited to Gram-negative bacteria such as Escherichia coli, Salmonella, Pasteurella, Pseudomonas aeruginosa and Haemophilus. Moreover, the resistance of these bacteria to commonly used aminoglycosides, penicillins, cephalosporins, fluoroquinolones, etc. is usually quite common; moreover, many bacteria have multi-drug resistance.

However, mucin sulfate is not susceptible to resistance, and no resistance has been found so far against the transmission of mucin sulfate resistance plasmids. Therefore, the spread of resistance to Colistin Sulphate is extremely slow, and the vast majority of Gram-negative bacteria are currently quite sensitive to Colistin Sulphate.

Production method of Colistin Sulphate Powder

Endotoxin is a toxin synthesized, produced and released by bacteria, consisting of O-specific side chains, core polysaccharides and lipid A. All antibiotics have the ability to cause bacterial infection. All antibiotics have been shown to cause problems with bacterial endotoxin release, but mucin sulfate has caused the least amount of bacterial endotoxin release.

More importantly, mucilage sulfate can neutralize endotoxin by binding to the negatively charged phosphate on the bacterially produced endotoxin lipid A through the positively charged -NH2; therefore, mucilage sulfate can eliminate bacterial endotoxin, inhibit the release and viability of bacterial endotoxin, and is a good anti-endotoxin drug.

According to Lü Genfa et al. (2004) and other studies, once endotoxin binds to the receptor on the cell surface and mediates cell activation, mucilage sulfate will lose its anti-endotoxin effect, thus supporting the direct neutralization of endotoxin by mucilage sulfate as the main way to antagonize endotoxin.

Mucilagin sulfate is a narrow-spectrum bactericide. It has strong antibacterial effect on Gram-negative bacteria such as Escherichia coli, Salmonella, Pasteurella, Dysenteria, Brucella, Vibrio, Pseudomonas aeruginosa, etc. The bactericidal mechanism is to damage the bacterial cell membrane, increase its permeability, make the bacteria leak amino acid, purine, pyrimidine, K+, etc. It can also affect the nucleoplasm and ribosome function, leading to bacterial death.

Bacteria are not easily resistant to this product, and there is complete cross-resistance with polymyxin B, but no cross-resistance with other antibacterial drugs, all Gram-positive bacteria and Aspergillus spp, Brucella spp, Serratia spp are resistant to this product. It is mainly used for the treatment of intestinal infections caused by Gram-negative bacilli and topical treatment of Pseudomonas aeruginosa infections caused by burns and trauma. As feed drug additive, it has the effect of promoting growth.

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