Sulfamonomethoxine Powder CAS 1220-83-3 Raw Materials

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Product details

Sulfamonomethoxine is one of the most powerful antibacterial drugs among sulfonamides, it is white or off-white crystalline powder, odorless, almost tasteless, darkening when exposed to light.

Sulfamonomethoxine Powder can be used to inhibit most Gram-positive and negative bacteria.Sulfamonomethoxine Raw Materials Sulfamonomethoxine Raw is a broad-spectrum antibacterial agent. is a broad-spectrum antibacterial drug, the most active sulfonamide in vitro and in vivo, with strong inhibitory effects on most gram-positive and negative bacteria, and bacteria are slow to develop.

Sulfamonomethoxine Raw is a broad spectrum antibacterial drug, the most active sulfonamide in vitro and in vivo, with strong inhibitory effects on most gram-positive and negative bacteria, and bacteria are slow to develop resistance to this drug.

Sulfamonomethoxine Powder is white or off-white crystalline powder, odorless and tasteless. Melting point is 204-206℃. Slightly soluble in water and ethanol, easily soluble in dilute acid, dilute alkali. Easily oxidized and darkened when exposed to light.

Uses and functions of Sulfamonomethoxine Powder.

Sulfamonomethoxine Powder has good antimicrobial effect on gram-positive and negative bacteria such as Streptococcus pyogenes, Salmonella and Pneumococcus.
Sulfamonomethoxine is structurally similar to p-aminobenzoic acid, which can compete with aminobenzoic acid for the enzyme dihydrofolate synthase in the bacterial body, hindering the synthesis of dihydrofolate and ultimately affecting the synthesis of nucleic acids and inhibiting the growth and reproduction of bacteria.

The effect of sulfonamides can be antagonized by aminobenzoic acid and its derivatives (procaine, bupivacaine). In addition, pus as well as tissue breakdown products provide substances essential for bacterial growth and antagonize sulfonamides.

Sulfamethoxazole, or sulfa-6-methoxypyrimethamine, is a strong antimicrobial agent, and also has a significant effect on coccidia and toxoplasmosis. It is easily absorbed internally, with low acetylation rate, not easy to produce crystal urine and hematuria, and is used for the treatment of various sensitive bacterial infections and avian coccidiosis and toxoplasmosis in pigs.

It has the strongest effect on Streptococcus, Pneumococcus, Salmonella, Bartonella, Corynebacterium septicum, Escherichia coli, and also has antimicrobial effect on Staphylococcus, Aspergillus, Bacillus anthracis and so on, so it is widely used in respiratory, gastrointestinal and urinary tract infections of livestock and poultry.

However, it is more commonly used for emergency treatment of outbreaks of leukocytosis and coccidiosis in poultry. It is also highly effective against toxoplasmosis in pigs. This product is a newer long-acting sulfonamides, the antibacterial spectrum is similar to sulfadiazine, but the antibacterial effect and protection against animal infections are stronger than other sulfonamides.

Sulfonamides for hemolytic streptococcus, pneumococcus and meningococcus and other infections use sulfamethoxazole as a broad-spectrum antimicrobial agent, hemolytic streptococcus, pneumococcus, Escherichia coli are effective. It is mainly used for the treatment of urinary tract infections, respiratory tract infections, and also kills Mycoplasma, worker and coccidiosis in animals.

Pharmacological Effects of Sulfamonomethoxine Powder.

Sulfamonomethoxine is a long-acting sulfonamide with antibacterial effects against non-enzymatic Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp. and other Enterobacteriaceae, Neisseria gonorrhea, Neisseria meningitidis, and Haemophilus influenzae.

Sulfonamides are broad-spectrum bacteriostatic agents. Its mechanism of action is structurally similar to p-aminobenzoic acid (PABA), can compete with PABA in the bacterial body of dihydrofolate synthase, thus preventing PABA as raw material for the synthesis of bacterial folic acid, reduce the amount of metabolically active tetrahydrofolate, which is the bacterial synthesis of purine, thymine nucleotides and deoxyribonucleic acid (DNA) of the necessary substances, and therefore inhibit the growth and reproduction of bacteria. Bacterial growth and reproduction were inhibited.

Production method of Sulfamonomethoxine Powder.

Sulfamonomethoxine sodium is commonly used in clinical practice, and the production method of Sulfamonomethoxine sodium includes the following steps:

• (1) Add sulfamonomethoxine and sodium hydroxide into an organic solvent, and stir the reaction for 0.5-2 hours under the temperature condition of 54-98℃ to obtain solution A;
• (2) Add activated carbon to solution A, stir to decolorize for 0.3-0.8 hours, filter while hot to get the filtrate;
• (3) The filtrate is first naturally cooled to 20-30 ℃, then at 0-5 ℃, keep warm for 1-3 hours, filtration, to get the filtrate;
• (4) Wash the filtrate with a small amount of anhydrous ethanol, and dry in vacuum at 55~60 ℃ for 2-4 hours, to obtain sodium sulfamoylmethoxypyrimidine.

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