Sulfadimethoxine Powder CAS 122-11-2 Raw Materials

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Sulfadimethoxine Powder Usage and Synthesis.

Sulfadimethoxine is a synthetic antimicrobial drug widely used in clinical practice.The antibacterial mechanism of Sulfadimethoxine Powder is mainly bacteriostatic, inhibiting the growth and reproduction of bacteria. 

Sulfadimethoxine Powder is effective against most Gram-positive bacteria, some Gram-negative bacteria, and ineffective against rickettsiae, mycoplasma, viruses, etc. 

Sulfadimethoxine Raw Materials is mainly used for the prevention and treatment of coccidiosis in calves, chickens and rabbits, and also used for the prevention and treatment of chicken infectious rhinitis and avian cholera.

Uses and functions of Sulfadimethoxine Powder.

The antimicrobial effect and clinical efficacy are similar to that of SD. It is rapidly absorbed and slowly excreted, with long duration of action, low rate of acetylation in vivo, and not easy to cause damage to the urinary tract.

In addition to broad-spectrum antibacterial effect, Sulfadimethoxine Powder also has significant anticoccidial and antitoxoplasmosis effects.

Sulfadimethoxine Powder is mainly used for the prevention and treatment of coccidiosis in calves, chickens and rabbits, and also used for the prevention and treatment of infectious rhinitis in chickens, avian cholera, Kashiwagi leukocyte protozoa, toxoplasmosis in pigs and dogs (often used in conjunction with ethyl pyrimethamine), and nocardia in dogs and cats, and it can be used for the prevention and treatment of bacterial gill disease, erectile scales, vibrio in fishes, eel red-fin disease, and boils in carp fishes.

Sulfadimethoxine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolate by inhibiting dihydrofolate synthase. Mode of action: Inhibits folate synthesis in prokaryotes. Antimicrobial spectrum: Gram-positive bacteria, Gram-negative bacteria, Chlamydia Antibiotic mechanism: alteration of dihydrofolate synthase or alternative pathways of folate synthesis.

Pharmacological Effects of Sulfadimethoxine Powder.

Sulfonamides can be categorized into sulfonamides for systemic infections, enteric sulfonamides, and topical sulfonamides based on the nature of their action and the length of their half-life.

Among them, sulfonamides for systemic infections can be divided into short-acting sulfonamides (half-life of about 6 hours), including sulfadoxine=methylpyrimidine, sulfadoxine=methylisopyrimidine, sulfisoxazole and so on; intermediate-acting sulfonamides (half-life of about 12 hours), including sulfadoxine-pyrimidine, sulfamethoxazole, sulfamethoxazole and so on;

Long-acting sulfonamides (with a half-life of more than 24 hours), including sulfamethoxypyrazine, sulfamethoxazole, sulfamethoxazole, sulfadimethoxine;

sulfamethoxypyridazine, sulfadimethoxine, and sulfadimethoxine.

Sulfonamide for intestinal use mainly acts as a bacteriostat in the intestinal tract, there are sulfadimethoxine, sulfosulfathiazole, phthalosulfathiazole, phthalosulfonylacetamide (restramil), laurozine sulfadiazine, and so on.

Topical sulfonamides mainly include sulfacetamide sodium, mesylate, silver sulfadiazine and so on.

Production method of Sulfadimethoxine Powder.

It is used to treat many infections including treatment of respiratory, urinary tract, enteric, and soft tissue infections. It is most frequently used in veterinary medicine. Sulfadimethoxine inhibits bacterial synthesis of folic acid (pteroylglutamic acid) from para-aminobenzoic acid. It is also commonly used for the treatment of coccidiosis in many species.

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