Related Attributes
Product details
Sulfadiazine Powder White or off-white crystals or powder, odorless, tasteless, fades to a darker color when exposed to light.Sulfadiazine CAS 68-35-9 Sulfadiazine is the silver salt of sulfadiazine, also known as burnsin, a sulfonamide for topical use on burn wounds.
It is produced by the action of sulfadiazine with sodium hydroxide.
Sulfadiazine Raw Materials is used for the treatment of infections of hemolytic streptococci, pneumococci, meningococci and others.
Sulfadiazine is a broad-spectrum antimicrobial drug but due to the fact that many common clinical pathogens are now resistant to this type of drug, it is only used for infections caused by sensitive bacteria and other sensitive pathogenic microorganisms.
Uses and functions of Sulfadiazine Powder.
Sodium sulfadiazine is the sodium salt of sulfadiazine, abbreviated as SD-Na. White crystalline powder odorless, slightly bitter taste, gradual discoloration when exposed to sunlight, long time placed in humid air slowly Chemicalbook slow absorption of carbon dioxide, the sulfonamide precipitation. Produced by the action of sulfadiazine and sodium hydroxide. It is used to treat infections of hemolytic streptococcus, pneumococcus, meningococcus and so on.
Sulfonamides are broad-spectrum antimicrobials, but because many common clinical pathogens are now resistant to this class of drugs, they are used only for infections caused by sensitive bacteria and other sensitive pathogenic microorganisms. The main indications for sulfadiazine (excluding the combination preparation of this class of drugs with methotrexate) are as follows:
Pharmacological Effects of Sulfadiazine Powder.
Sulfadiazine is an intermediate-acting sulfonamide with antibacterial activity against non-enzyme-producing Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Enterobacteriaceae such as Klebsiella, Salmonella, Shigella, gonococcus, meningococcus and Haemophilus influenzae, and also has anti-microbial activity against Chlamydia trachomatis, Nucella satellitans, Plasmodium falciparum and Toxoplasma gondii in vitro. The antibacterial activity of this product is the same as sulfamethazine.
However, in recent years, the resistance of bacteria to this product has increased, especially Streptococcus, Neisseria and Enterobacteriaceae.
Sulfonamides are broad-spectrum antibacterial agents. This product is structurally similar to p-aminobenzoic acid (PABA), can compete with PABA in the bacterial body of dihydrofolate synthetase, thus preventing PABA as a raw material for the synthesis of bacterial folic acid, reducing the amount of metabolically active tetrahydrofolate, which is the bacterial synthesis of purine, thymine nucleosides and deoxyribonucleic acid (DNA) of the necessary substances, so inhibiting the bacterial growth and reproduction. growth and reproduction.
Sulfadiazine is a sulfonamide anti-infective drug commonly used in clinical practice, also known as sulfadiazine pyridazine, diazoxide, sulfadiazine's molecular structure is similar to p-aminobenzoic acid (PABA), which can compete with PABA in the bacterial body of the dihydrofolate synthetase, thus preventing the synthesis of folic acid required by the bacteria as a raw material of PABA, and reducing the amount of metabolically active tetrahydrofolate, which is essential for the synthesis of bacteria, purines, thymine nucleosides and deoxyribonucleic acid (DNA). purine, thymine nucleosides, and deoxyribonucleic acid (DNA), thus inhibiting bacterial growth and reproduction.
Sulfadiazine inhibits sensitive bacteria such as hemolytic streptococci, staphylococci, meningococci, pneumococci, gonococci, Escherichia coli, and dysentery bacilli, as well as microorganisms such as Chlamydia trachomatis, Actinobacillus, Plasmodium, Nucella asteroides, and Toxoplasma gondii.
Sulfadiazine has the advantages of high effective concentration in blood, low serum protein binding rate, easy penetration of the drug into the cerebrospinal fluid, the drug of choice for the treatment of epidemic meningitis, but in recent years there has been an increase in the number of resistant strains of Sulfadiazine and other sulfonamides by Meningococcus meningitidis (20% of the domestic reports, 33% of the foreign reports of resistance to this product).
Production method of Sulfadiazine Powder.
Propargyl alcohol method: Propargyl alcohol is made from acetylene and formaldehyde under pressure (1.96~2.3MPa) by catalytic (copper acetylene as catalyst) acetylation reaction. Then by catalytic oxidation (2.36MPa) to get propargyl aldehyde, and at the same time with the addition of diethylamine to get diethylaminopropenal. Then it is condensed with sulfaguanidine and refined into sulfadiazine by acid precipitation.
Why choose us?
HRK Factory
About Shipping
Pharmaceutical Intermediate manufacturers
©2022 Xi'an Henrikang Biotech Co., Ltd.,
Home
E-mail
Booking