Sulfaguanidine Solution Powder CAS 57-67-0 Raw Materials

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Sulfaguanidine Solution Powder Usage and Synthesis.

Sulfaguanidine Solution is white needle-like crystalline powder, odorless or almost odorless, tasteless. It changes color gradually when exposed to light. Sulfaguanidine is a low-grade sulfonamide drug that inhibits bacteria.

Sulfaguanidine Solution Powder is mainly used in the production of sulfadiazine, sulfadimethoxine, and other high-grade sulfonamides. The drug of choice for the treatment of leprosy is a low-grade sulfonamide drug that inhibits bacteria. choice for the treatment of leprosy. 

The drug of choice for the treatment of leprosy, Sulfaguanidine Solution Raw Materials is suitable for the treatment of all types of leprosy and can improve clinical symptoms. Sulfonamides are used for bacterial dysentery and enteritis. Sulfonamides are used for bacterial dysentery and enteritis.

Sulfonamides are used for bacterial dysentery and enteritis. The drug of choice for the treatment of leprosy is suitable for the treatment of all types of leprosy and can improve clinical symptoms. It can improve clinical symptoms. Sulfonamides is used for the treatment of all types of leprosy, and can improve clinical symptoms. It can improve mucosal lesions faster, skin lesions more slowly, and neuropathy even slower, so it has a long course of treatment, and is prone to drug resistance, and is not easy to be cured radically.

Preparation for tablets. Uses This product is a sulfonamide drug, used for intestinal antibacterial infections, such as bacterial dysentery enteritis, can also be used for intestinal surgery before the prevention of infection. In the pharmaceutical industry, it is generally used as an important raw material for SM2, SD and other sulfasalazine drugs.

Uses and functions of Sulfaguanidine Solution Powder.

Sulfaguanidine is a low-grade sulfonamide drug, which can inhibit bacteria. It is mainly used for the production of sulfadiazine, sulfadimidine and other high-level sulfonamides.

Sulfadiazine and sulfadimidine were once commonly used in sulfonamides, but due to their high toxicity, they are generally not used as the drug of choice, and now they and p-acetamidobenzenesulfonyl chloride are only used as intermediates in the production of sulfonamides.

Sulfaguanidine, also known as sulfaguanidine, dysentery tablets, the earliest sulfonamides used for intestinal infections, sulfaguanidine molecular structure has a strong basic guanidine group, the dissociation degree is large, the fat solubility is small, although there is a certain amount of intestinal absorption after intake, but not enough to reach the effective blood concentration, so it is not used for systemic infections. However, it can maintain a higher concentration in the intestines, and is mostly used for bacterial infections in the digestive tract.

Such as gastroenteritis, dysentery, etc. Combined with antimicrobial potentiator methotrexate (TMP) or dimethoate (DVD), its antibacterial effect is significantly enhanced.

Pharmacological Effects of Sulfaguanidine Solution Powder.

• 1, concomitant application of urinary alkalinizing drugs can enhance the solubility of the product in alkaline urine, resulting in increased excretion.
• 2, Sulfaguanidine should not be combined with p-aminobenzoic acid, which can be taken up by bacteria instead of this product, and the two are antagonistic to each other. Also should not be combined with p-aminobenzoic acid-containing local anesthetic drugs such as procaine, bupivacaine and so on.
• 3, For those taking estrogen-based contraceptives, the concomitant prolonged application of sulfadiazine can lead to a decrease in the reliability of contraception and an increase in the chance of extra-menstrual bleeding.
• 4, An additive effect of photosensitization may occur when combined with photosensitizing drugs.
• 5, The requirement for vitamin K is increased in patients treated with this product.

Production method of Sulfaguanidine Solution Powder.

Condensation of sulfanilamide with guanidine nitrate.

• 1, Sulfaguanidine can be produced by melting sulfanilamide and guanidine nitrate in soda ash and condensing under reduced pressure.
• 2, It can be produced by reacting acetylsulfamoyl chloride with guanidine nitrate in the presence of sodium hydroxide in a mixed solution of acetone and water.
• 3, Sulfamidine can be produced by catalytic hydrogenation of p-nitrobenzenesulfonyl chloride as raw material to produce p-aminobenzenesulfonyl chloride, then ammoniated to produce sulfonamide, then reacted with guanidine nitrate.

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