Veterinary Medicine Ofloxacin Powder CAS 82419-36-1 Raw Materials

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Ofloxacin Powder Usage and Synthesis.

Ofloxacin Powder is clinically used for acute and chronic infections of the respiratory tract, pharynx, tonsils, urinary tract including prostate, skin and soft tissues, intestines and otorhinolaryngology caused by sensitive bacteria. skin and soft tissues, intestines and otorhinolaryngology caused by sensitive bacteria. 

The third generation of quinolone synthetic antibacterial drugs, Veterinary Medicine Ofloxacin has the advantages of wide antibacterial spectrum, strong antibacterial activity, good bioavailability of quinolone and other antibacterial drugs.  Nalidixic acid analogs, Ofloxacin Raw Materials has a broad-spectrum anti-bacterial activity. Bacterial activity

Uses and functions of Ofloxacin Powder.

Third generation quinolone synthetic antimicrobials, with the advantages of broad antibacterial spectrum, strong antibacterial activity, good bioavailability, safe and effective for oral administration, low toxicity and no drug resistance.

It has good antimicrobial effect on a variety of Gram-positive and Gram-negative bacteria, and also has antimicrobial effect on Pseudomonas aeruginosa and Chlamydia.

For strains resistant to neopenicillin, clindamycin, gentamicin and strains resistant to haloperidol, the product works well without cross-resistance. In addition, it also has a certain antibacterial effect on anaerobic bacteria.

It is used for respiratory infections, intestinal infections, skin and soft tissue infections, urinary system infections caused by sensitive bacteria.

Ofloxacin is widely used in combination with other antibiotics, antipyretic and analgesic drugs, antiviral drugs, immunomodulators or developed into compound preparations. According to the market survey, some provinces and cities have approved more compounded ofloxacin preparations, such as ofloxacin diclofenac sodium injection, ofloxacin hydrochloride levamisole tablets, etc., to expand the antimicrobial spectrum for comprehensive prevention and treatment, especially for streptococcus, pneumococcus spp., mycoplasma, anaerobic spp. and so on, for which the efficacy of other antibiotics is relatively poor, has a good effect. The common pairing medicines are:

1. ① with astragali polysaccharide, panax quinquefolium or Qianlong and other antiviral drugs, used for bacterial and viral combined infections;
2. ② with anacin or diclofenac sodium, ketorolac and other antipyretic and analgesic drugs, used for bacterial fever;
3. (3) Compounding with herbs such as fritillaria and chaihu for summer fever;
4. ④ Compounded with metronidazole for severe anaerobic infections;
5. ⑤ Combined with doxycycline hydrochloride and sulfonamides for blood protozoa;
6. (6) Combined with dysentery and safranin, used for intestinal disorders.

Pharmacological Effects of Ofloxacin Powder.

This product has the third generation of quinolone antibacterial activity, staphylococcus, streptococcus, Streptococcus pneumoniae, Neisseria gonorrhoeae, Citrobacter, Shigella, Klebsiella pneumoniae, Enterobacter, Serratiaceae, Aspergillus, Haemophilus influenzae, Fusobacterium indolentum, Campylobacter and so on, also has a certain antibacterial effect on Pseudomonas aeruginosa and Chlamydia trachomatis, and has the role of anti-tuberculosis mycobacteria, can be combined with isoniazid, can be used for intestinal diseases. It can be used together with isoniazid and rifampicin to treat tuberculosis.

It has strong antibacterial effect on both gram-positive and negative bacteria. It also has good effect on anaerobic bacteria and Mycoplasma pneumoniae. The antibacterial activity of Ofloxacin is 4-8 times stronger than that of haloperidol against Aureus and hemolytic streptococcus.

Production method of Ofloxacin Powder.

Taking 2,3,4-trifluoronitrobenzene as the starting material, the product is obtained by selective alkali hydrolysis, etherification, reduction, condensation with C2H5OCH=C(COOEt)2 or (CH3)2NCH=C(COOEt)2, cyclohexylation, hydrolysis, and the action of boron acetate, and then the introduction of N-methyl piperazine.

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