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Yangmeiin is a flavonoid compound extracted from the fruit of Yangmei, which has a variety of effects such as scavenging free radicals, antioxidant, anti-tumour, reducing neurotoxicity,
affecting the activation and proliferation of lymphocytes, anti-platelet activating factor, lowering blood glucose, lifting alcohol toxicity, preventing alcoholic liver, fatty liver, inhibiting the
deterioration of hepatocytes, lowering the incidence of hepatocellular carcinoma, protecting the liver and liver, anti-inflammatory and other effects, and it can also strongly inhibit the yeast alpha
glucosidase, gluco (gluco) glucosidase I, gluco (gluco) glucosidase I in vitro, and the milk in the xanthine oxidase.
Uses of Myricetin.
1) Antioxidant effects: populin is a strong antioxidant and oxidative stress plays a key role in various neurological disorders including local ischaemia and age-related dementia. Populin acts
through conformational changes to reduce the production and toxicity of β-amylase, which can be used to statistically determine the progression of dementia.
2) Anti-tumour effects: populin is a potent chemopreventive agent for carcinogenic effects.
3）Reducing neurotoxicity: populin can inhibit the neurotoxicity caused by glutamate to protect neurons through different pathways, thus effectively stopping nerve damage.
(4) Effect on lymphocyte activation and proliferation: populin can inhibit the expression of CD69,an early activation indicator of T-cells, and inhibit the proliferative response of lymphocytes.
(5) Platelet-activating factor (PAF) antagonism: Yangmeiin inhibited PAF-induced WRP aggregation and 52HT release in vitro in a concentration-dependent manner.
At the same time, it can significantly inhibit the increase of free calcium in platelets caused by PAF. Therefore, populin has various cardiovascular pharmacological effects such as antithrombotic, anti-myocardial ischemia, and improvement of microcirculation.
(6) Hypoglycaemic effect: Yangmeiin has more obvious hypoglycaemic effect.
(7) Hepatoprotective effect: dihydromyricetin can significantly inhibit the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity and reduce serum total bilirubin, there are obvious enzyme-lowering effect of yellow.
Pharmacological Effect of Myricetin.
(1) Antagonistic effect of platelet-activating factor (PAF). It has various cardiovascular pharmacological effects such as antithrombotic, anti-myocardial ischaemia, and improvement of
microcirculation.
Yangmeiin can significantly inhibit the increase of free calcium in platelets caused by PAF, and inhibit the specific binding of PAF to rabbit platelet receptor. It shows that populin has anti-PAF
effect and is a new PAF receptor antagonist.
(2) Hypoglycaemic effect;
Yangmeizin has obvious hypoglycemic effect on diabetic mice caused by tetroxine and hyperglycemic mice caused by adrenaline and glucose with good therapeutic effect, but it has no
obvious effect on blood glucose of normal mice. In addition, in their further research, they found that populin has a good hypoglycaemic effect on a variety of animal models, and it is expected to develop hypoglycaemic drugs or be used as food additives for diabetic patients.
(3) Antioxidant effect;
A study using the Rancimat method to determine its antioxidant properties, the results show that its oil is an excellent antioxidant, the role is significantly stronger than the synthetic antioxidant
BHT (3,5-di-tert-butyl-4-hydroxymethylbenzene) can be used as a natural antioxidant applied to the higher oil and grease on the preservation of food. Another study showed that populin is a
strong antioxidant, oxidative stress plays a key role in a variety of neurological diseases including local ischaemia and dementia in old age.
(4) Liver protection and hepatoprotection;
Yangmei barkin can significantly reduce carbon tetrachloride, D2 galactosamine and naphthyl isothiocyanate caused by acute liver injury model mouse serum toxic content, reduce liver tissue
degeneration and necrosis; and improve mononuclear macrophage phagocytosis function and haemolysin content. It shows that poplar plum barkin has hepatoprotective and enzyme-reducing
and anti-yellowing properties, enhances non-specific immune function in mice and humoral immune function in immunocompromised mice, and thus plays a hepatoprotective role, which
provides a reference for the clinical application of poplar plumin.
(5), relieve light ethanol poisoning;
Yangmeiin has the effect of detoxification of alcohol poisoning. Afterwards, when the mechanism research was conducted, it was found that the principle that populin can relieve ethanol
poisoning is mainly to protect the liver and reduce the damage of hexanol to the liver.
6), the active ingredients in the bark and leaves of prunus yangmai, in addition to the above proven pharmacological effects, but also has a variety of pharmacological activities such as anti-
inflammatory, anti-tumour, anti-mutagenesis, prevention of dental caries, antioxidant properties,the elimination of free radicals in the body.
Preparation Method of Bulk Myricetin Powder.
Dihydromyricetin is mixed with alcohols, then sodium hypochlorite solution and catalyst are added, and after the reaction is complete, sodium hypochlorite solution is continued to be added
to obtain myricetin. In this method, the alcohol is methanol or ethanol and the catalyst is anhydrous aluminium trichloride or anhydrous ferric trichloride.
This method takes dihydromyricetin as the starting material and prepares the product, populin,after semi-synthesis; since dihydromyricetin is obtained from the plant Garcinia cambogia with a
content of more than 98%, the cost is low, the operation is simple, the product yield is high, and the product does not need to be refined, with a content of more than 98%, which is applicable to the industrialised production.
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