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Isoglycyrrhizin is a flavonoid that can be extracted from the herb liquorice. It has a wide range of pharmacological effects, including anticancer, antioxidant, and anti-inflammatory.
In one study, isoglycyrrhizin was shown to inhibit the growth of pancreatic cancer cells and kill tumour cells by inducing apoptosis and autophagy. In addition, another study found that isoglycyrrhizin could hinder the development of prostate and colon cancer.
However, due to the lack of research, further studies and explorations on the role and safety of isoglycyrrhizin in humans are still needed. Meanwhile, it is important to note that consuming large amounts of liquorice may trigger adverse effects, such as reduced potassium levels and increased blood pressure.
Uses of Isoliquiritigenin.
Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants that displays antioxidant, anti-inflammatory and antitumor activities as well as hepatoprotection against steato sis-induced oxidative stress. ISL induces quinone reductase-1, a phase Il enzyme that deactivates radicals and electrophiles, with a concentration required to double activity (CD) value of 1.8 μM in murine hepatoma cells.
Pharmacological Effect of Isoliquiritigenin.
Isoglycyrrhizin is a flavonoid extracted from the Chinese herb liquorice, which has a wide range of pharmacological effects. It is also widely used in cosmetics and food additives, among others.
In cancer therapy, isoglycyrrhizin was found to have anticancer effects, inhibiting the growth of pancreatic cancer cells and killing tumour cells by inducing apoptosis and autophagy [.
In addition, isoglycyrrhizin has detoxifying, anti-inflammatory, antitussive, anti-tumour, anti-ulcer and antibacterial effects. Its main components include glycyrrhizin, glycyrrhizin, glycyrrhizin flavonoids, posterior maku-bidanin, spiny mangosteen, quercetin, etc.
In vitro studies of Bulk Isoliquiritigenin Powder.
Isoliquiritigenin may be effective in preventing diabetic complications by inhibiting rat lens aldose reductase with an IC50 of 320 nM and in preventing sorbitol accumulation in human erythrocytes with an IC50 of 2.0 μM.Isoliquiritigenin may be used as a whitening agent by inhibiting monophenol tyrosinase and diphenol tyrosinase activity. whitening agent with an IC50 of 8.1 μM.
Isoliquiritigenin induces cell cycle arrest and inhibits cell growth in DU145 and LNCaP cell lines. In human gastric cancer MGC-803 cells, Isoliquiritigenin induced apoptosis by increasing intracellular free calcium ion concentration and decreasing mitochondrial membrane potential (Deltapsi(m)).
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