Lentinan Raw Materials Lentinan Powder

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Lentinan Usage and Synthesis.

Shiitake mushroom polysaccharide is an immune enhancer, an antitumor adjuvant, which has no direct antitumor effect per se, but works synergistically through the activation of the host's disease prevention mechanisms, including the activation of cytotoxicity of killer T-cells, macrophages, natural killer cells (NK), and antibody-dependent macrophages (ADMC) and the restoration of function of the suppressed helper T-lymphocytes, and the increase of interleukins and interferons in the blood. It further activates the immune system and has a significant protective effect on the liver.

Used alone or in combination with other antineoplastic drugs, it has inhibited the proliferation of a variety of animal tumours, especially when used with Tegafur (FT-207), the survival of patients is significantly prolonged compared with that used alone.

Uses of Lentinan.

Used in conjunction with chemotherapeutic drugs for patients with gastrointestinal tumours, it can prolong the survival time, prevent leukopenia or decrease in total serum protein has a certain efficacy in chronic viral hepatitis B, can significantly improve the patient's symptoms, so that the serum ghrelin transaminase to normal or better, and can adjust the patient's immune function.

Immune enhancer. Used for patients with inoperable or recurrent gastric cancer.

Precautions: anaphylaxis, leukocyte and haemoglobin reduction symptoms may occasionally occur. Children and women of pregnancy and childbearing age should be used with caution.

Extraction method of Lentinan.

At present, the extraction of mushroom polysaccharides is mostly carried out in hot water and dilute alkaline solution, avoiding strong acid and alkaline solution, otherwise it is very easy to cause glycosidic bond breakage and conformational changes in polysaccharides.

The commonly used separation and purification methods generally go through the steps of boiling water extraction, ethanol precipitation, dialysis and column chromatography.

Considering that there are other physiologically active components (e.g., adenine, tyrosine oxidase and vitamin D, etc.) in shiitake mushrooms, the final product should be defined and the purpose of extraction should be clarified when the extraction method is determined. Generally, the mushroom substrate is first crushed, stirred and extracted with 90-100℃ water for 3-5h, repeated 2-3 times, and then extracted with 0.5 mol/L NaOH solution, initially the polysaccharides are divided into water-soluble and alkaline-soluble two parts.

Then the mushroom residue was removed, and the supernatant was dialysed or ion-exchanged to remove small molecule impurities, and the crude product could be obtained after ethanol or thiamine precipitation. In the above extraction process, if the mushroom powder is treated with some compound enzyme preparation in advance, the rate of polysaccharide can be greatly improved.

Product Method of Bulk Lentinan Powder.

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