Camptothecin Raw Materials powder Camptothecin

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Camptothecin powder Usage and Synthesis.

It is mainly used for digestive tract tumors, and has good effect on gastric cancer, rectum and colon cancer, and can improve the chance of surgical resection of advanced gastric cancer. It has certain curative effect on cylindroid adenocarcinoma of head and neck, bladder and lung. For primary liver cancer, it can shrink the tumor, and intravenous injection of camptothecin emulsion can increase the chance of surgical resection of liver cancer. It is also effective for malignant mole and chorionic epithelial carcinoma. Antitumor alkaloids.

Irreversibly binds to the DNA-topoisomerase I complex, inhibits DNA rebinding after topoisomerase I cleavage, and causes the enzyme to form a covalent link with DNA. A cytotoxic antitumor drug.

Uses and functions of Camptothecin.

Anticancer effect

Camptothecin is a plant anticancer drug, which is the "third largest plant anticancer drug" in the world.

Camptothecin and its derivatives are a kind of broad-spectrum anticancer drugs, which can cause morphological changes such as degeneration, necrosis and nucleopytosis of cancer cells, and change the ultrastructure of cancer cells and host hepatocytes. Camptothecin mainly acts on the DNA synthesis phase of cells.

Antiviral effect

Camptothecin can inhibit HIV replication in the cells of patients with acute HIV infection by 89% to 93%, and is a natural drug for the treatment of AIDS. Camptothecin can also treat condyloma acuminatum, especially for children condyloma acuminatum has a better therapeutic effect. Condyloma acuminatum is caused by human papillomavirus benign neoplasm of the skin mucosa, camptothecin treatment mechanism of condyloma acuminatum is mainly to promote the apoptosis of condyloma acuminatum epithelial cells, inhibit the excessive proliferation of epithelial cells.

Synthesis method of Camptothecin.

Product method of Bulk Camptothecin.

This alkaloid is extracted from the roots, skins and fruits of Camptotheca davidia. It can also be produced synthetically. The crude camptotheca acuminata powder was soaked in 10 times 80% ethanol for 24 hours, the percolate was collected, and the ethanol was recovered by concentration under reduced pressure. The concentrated liquid was placed in the clear liquid and extracted with chloroform. The extracted liquid was distilled to recover the chloroform until dry, and then methanol solution was added for cooling and filtration. The filter cake was made into crude camptothecin, and the crude product was recrystalized with mixed solvent methanol-chloroform to obtain camptothecin. The total yield of fruit juice was 0.03-0.04%.

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