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Doxorubicin is a non-cycle specific anti-tumor drug with a wide anti-tumor spectrum, and can be clinically used in breast cancer, lung cancer, lymphatic cancer, ovarian cancer and other cancers. As a second-line anti-tumor drug, doxorubicin can be used for treatment when the preferred drug is resistant.
Doxorubicin hydrochloride is a non-periodic anti-tumor drug with a wide anti-tumor spectrum. It can be clinically used for breast cancer, lung cancer, lymphatic cancer, ovarian cancer and other cancers. As a second-line anti-tumor drug, doxorubicin can be used for treatment when the preferred drug is resistant.
Doxorubicin hydrochloride inhibits DNA topoisomerase II by embedding and inhibiting the interaction between polymer biosynthesis and DNA. Doxorubicin hydrochloride prevents the closing of the DNA double helix, thereby disrupting the replication of the DNA strand. By embedding, doxorubicin can also act on transcriptionally active chromatin, resulting in histone changes. The results showed that DNA damage response, epigenome and transcriptome were not controlled in doxorubicin affected cells.
Uses of Doxorubicin hydrochloride.
Antitumor antibiotic that has doxorubicin effects on cardiac mitochondrial DNA. Inhibitor of reverse phase transcriptase and RNA polymerase, immunosuppressant; It can be inserted into a DNA strand. Clinically, it is a cancer chemotherapy agent, mainly used for acute and chronic leukemia and malignant lymphoma.
Doxorubicin hydrochloride is an antitumor antibiotic, which can penetrate into cells and cross and bind with tumor cell DNA, inhibit DNA replication, block the action of RNA polymerase, and inhibit RNA synthesis. Its cytotoxic effect is related to the formation of free radicals, the binding and breaking of tumor cell membrane. Widely used in cell culture or rat nephropathy, myocardial ischemia and other aspects of modeling materials; Used to inhibit macromolecular biosynthesis
For the treatment of acute lymphoblastic leukemia, acute myeloid leukemia, Hodgkin's disease and non-Hodgkin's disease lymphoma, breast cancer, lung cancer, ovarian cancer.
Pharmacological action of Doxorubicin hydrochloride.
Doxorubicin hydrochloride inhibits topoisomerase II of DNA superhelix by embedding and inhibiting the interaction between polymer biosynthesis and DNA. Doxorubicin prevents the closing of the DNA double helix, thereby disrupting the replication of the DNA strand. By embedding, doxorubicin can also act on transcriptionally active chromatin, resulting in histone changes. The results showed that DNA damage response, epigenome and transcriptome were not controlled in doxorubicin affected cells.
Product Method of Bulk Doxorubicin hydrochloride Powder.
It was obtained from culture medium of Str.Peucetius var.Caesius. The chemical structure of this product is similar to daunorubicin, so it can be prepared by chemical conversion of daunorubicin. At present, it can be fully synthesized chemically.
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