Pharmaceutical raw materials anti-tumor Osimertinib Mesylate

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Osimertinib Mesylate Powder Usage and Synthesis.

1. Improve sequelae of cerebral infarction

By promoting the increase of cerebral blood flow to prevent ischemic injury, thereby reducing the movement disorders and other sequelae caused by cerebral infarction.

2. Improve cerebral arteriosclerosis

The drug has the effect of dilating blood vessels, reducing blood viscosity, and then alleviating the pathological process of cerebral arteriosclerosis.

3. Improve brain function decline

4. Improve the sequelae of brain trauma

It can stimulate the central nervous system, promote neuron regeneration, and help restore damaged brain function.

5. Improve cerebral vasospasm

Because it has the effect of dilating vascular smooth muscle, it can reduce the local blood supply shortage caused by cerebral vasospasm.

Pergolide mesylate should be monitored when using blood pressure changes to avoid too low or too high blood pressure due to drug side effects. Patients should also regularly review the relevant examination items, such as head CT, MRI, etc., to evaluate the progress of the disease and treatment effect. The diet should be light and rich in nutrients, avoid spicy and irritating foods.

Uses of Osimertinib Mesylate.

Preparation of Osimertinib Mesylate.

With 4 - fluoro - 2 - methoxy - 5 - nitroaniline with 3 - (2 - chloro pyrimidine - 4 - base) - 1 - methyl indole reaction under the catalysis of monohydrate for N - (4 - fluoro - 2 - methoxy - 5 - nitrobenzene) - 4 - (1 - methyl - 1 h - indole - 3 -) pyrimidine - 2 - amine, after using N, N, N '- trimethyl ethylenediamine instead of fluorine, The nitro group was reduced with ferric ammonium and then reacted with 3-chloropropionyl chloride and then eliminated to obtain AZD9291 with a yield of 17.5%. AZD9291(mesylate) was prepared by salting AZD9291 with mesylate.

Product Method of Bulk Osimertinib Mesylate Powder.

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