Cyclophosphamide Powder CAS 50-18-0 Raw Material

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Cyclophosphamide Powder Usage and Synthesis.

Cyclophosphamide Powder is one of the most commonly used alkylating agents for the treatment of malignant lymphoma, multiple myeloma, lymphocytic leukemia, cervical cancer, prostate cancer, colon cancer, bronchial cancer, solid tumors such as neuroblastoma, ovarian cancer, breast cancer. Cyclophosphamide Raw Material is also used in the treatment of rheumatoid arthritis, childhood nephrotic syndrome Cyclophosphamide is also used in the treatment of rheumatoid arthritis, childhood nephrotic syndrome and autoimmune diseases.

Cyclophosphamide is one of the most commonly used alkylating antitumor agents. It is a white crystalline or crystalline powder at room temperature (liquefies when it loses its water of crystallization) and is stable at room temperature. It is soluble in water, but not very soluble. Aqueous solution is unstable, so it should be used within a short time after dissolution.

Soluble in ethanol. first synthesized by Arnold and Bourseaux in 1958, the synthesis of this compound and its derivatives was developed based on the structure and action of previous anticancer drugs. It is mainly used for tumor immunity, and after entering the human body, it is catalyzed by liver microsomal enzymes to divide into alkylated phosphoramidite (or phosphoramidite nitrogen mustard),

which has cytotoxic effect on tumor cells, and has obvious inhibitory effect on many kinds of tumors, and has been used for the treatment of many autoimmune diseases in recent years because of its immunosuppressive effect, and has achieved obvious efficacy.

Uses and functions of Cyclophosphamide Powder.

It is suitable for the treatment of malignant lymphoma, multiple myeloma, lymphocytic leukemia, cervical cancer, prostate cancer, colon cancer, bronchial cancer, solid tumors such as neuroblastoma, ovarian cancer, breast cancer, various sarcomas and lung cancer. It is also used in the treatment of rheumatoid arthritis, childhood nephrotic syndrome, and autoimmune diseases.

Pharmacological Effects of Cyclophosphamide Powder.

Cyclophosphamide (abbreviated as CTX) is a non-specific cytotoxic drug of the cell cycle, but has a more potent effect on the G2 phase (late DNA synthesis).

The main immunosuppressive mechanisms are:

1. Decrease in the absolute number of T and B lymphocytes, more pronounced in the early phase on B lymphocytes.

The main immunosuppressive mechanisms are:
① Decrease in the absolute number of T and B lymphocytes, more pronounced for B lymphocytes in the early stage. The inhibition after mitogen stimulation was not as strong as for specific antigens.

③Inhibits antibody responses to neoantigens and delayed skin metaplasia.

④Reduces elevated immunoglobulin levels, with the possibility of hypogammaglobulinemia after long-term use (several years).

⑤ In vitro selective inhibition of B-lymphocyte function, reduction of spontaneous immunoglobulin production by some B-lymphocytes, and inhibition of immunoglobulin production following stimulation of mitogens in general. Cyclophosphamide is not cytotoxic before metabolism, and its activation must depend on the oxidation of cytochrome P450 in the microsomal enzyme system of hepatocytes to form 4-hydroxycyclophosphamide, which then turns into the highly active phosphoramidite nitrogen mustard after ring opening, thus exerting cytotoxic effects.

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