Dacarbazine Powder CAS 4342-03-4 Raw Materials

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Dacarbazine Powder Usage and Synthesis.

Dacarbazine Powder is a new class of purine precursor antineoplastic agents that interferes with purine biosynthesis and acts as an alkylating agent. Dacarbazine Raw Materials is mainly used clinically as the citrate salt of Dacarbazine CAS 4342-03-4, a white crystalline powder. 

Dacarbazine Raw Materials is more acidic in aqueous solution, pH 1.9-2.3. 

Dacarbazine Raw Materials is mainly used in malignant melanoma and is more effective than hydroxyurea. 

Dacarbazine Raw Materials is mainly used in malignant melanoma and is more effective than hydroxyurea. Also used in squamous and undifferentiated carcinoma of the lung, smooth muscle sarcoma, fibrosarcoma, etc. It is not effective in gastrointestinal tumours.

Uses and functions of Dacarbazine Powder.

Anti-tumor agent. It is clinically effective in malignant melanoma in about 20-30% of cases, and can be used in combination with vincristine and capsazepine to improve the efficacy. It is also effective against squamous lung cancer, sarcoma, smooth muscle sarcoma and fibrosarcoma. It is not effective against carcinoma of the gastrointestinal tract.

In disseminated malignant melanoma, the efficacy is better than other anti-cancer drugs. Most often used as single agent therapy, but can also be used in combination with BCG, transfer factor and milphalan for immunochemical combination therapy. With (ABVD), (MOPP), in certain patients with advanced Hodgkin's disease with poor prognosis, alternating the 2 combination chemotherapies can result in long-term complete remission or even cure. It is effective in various sarcomas, brain tumours, squamous cell carcinoma and small cell carcinoma of the lung, as well as neuroblastoma in children.

Slightly yellow crystals or powder. Melting point 205℃, also reported 250-255℃ (decomposition). Freely soluble in acid, slightly soluble in methanol, ethanol, insoluble in water. Decomposes in heat and is unstable to acid and light.

Pharmacological Effects of Dacarbazine Powder.

The structure of dacarbazine is an analogue of purine biosynthetic precursors (see Figure 1), but has similar biological effects to alkylating agents and is a non-specific cell cycle drug. It has inhibitory effects on several experimental animal tumours, mainly in the G2 phase of the cell cycle, and inhibits RNA and protein synthesis more than DNA.

• 1. The dosage of this product should be reduced when used in combination with other drugs that inhibit bone marrow.
• 2. There is an increased risk of allergic reactions when used in combination with adiponectin.
• 3. Vaccination with live vaccines when using this product will increase the risk of live vaccine infection. Live vaccines should not be administered to patients receiving immunosuppression. Patients with leukaemia in remission should be discontinued for at least 3 months before receiving live vaccines.
• 4. Dacarbazine and hydrocortisone sodium succinate are contraindicated and should not be used together.

Production method of Dacarbazine Powder.

It is obtained from ethyl cyanoacetate by addition, amination, diazotization, coupling, reduction, formylation, cyclization, neutralization, diazotization, condensation and intermediates β-imino-β-ethoxypropionic acid ethyl ester hydrochloride, α-amidinylacetamide hydrochloride, α-amidinyl-α-phenylazoacetamide hydrochloride, 5-aminoimidazole-4-carboxamide hydrochloride.

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