Related Attributes
Product details
Sulfachloropyrazine sodium, chemical name: 4-Amino-N-(6-chloro-2-pyrazinyl)benzenesulfonamide sodium monohydrate. White or yellowish powder.
Sulfachloropyrazine sodium can compete for dihydrofolate synthase and affect the synthesis of dihydrofolate, thus inhibiting the growth and reproduction of bacteria and coccidia.
Sulfachloropyrazine sodium has similar action characteristics to sulfaquinoxaline on poultry coccidia, but with stronger antibacterial effect, it can even treat avian cholera and chicken typhoid, so it is most suitable for the treatment of coccidiosis outbreak.
Uses of Sulfachloropyrazine sodium.
Sulfachloropyrazine sodium is a specialised sulphonamide drug against coccidiosis, which is widely used in livestock and poultry coccidiosis. It can compete with dihydrofolate synthase to affect the synthesis of dihydrofolate, thus inhibiting the growth and reproduction of bacteria and coccidia.
Sulfachloropyrazine sodium is similar to sulfaquinoxaline in its action against coccidiosis in poultry, but it has stronger antibacterial effect, and it can even treat avian cholera and fowl typhoid, so it is the most suitable for the treatment of coccidiosis outbreaks.
Sulfachloropyrazine sodium is a special sulphonamide for anti-coccidiosis, widely used in livestock and poultry coccidiosis.
Sulfachloropyrazine sodium can compete with dihydrofolate synthase and affect the synthesis of dihydrofolate, thus inhibiting the growth and reproduction of bacteria and coccidia.
Sulfachloropyrazine sodium has similar action characteristics to sulfaquinoxaline on coccidiosis in poultry, but with stronger antibacterial effect, and can even treat avian cholera and fowl typhoid, so it is the most suitable for the treatment of coccidiosis outbreaks.
Sulfonamide antibacterial drugs, used for livestock E. coli and bacillus infections, and methotrexate and sucrose configuration of the compound sulfachloropyridazine sodium salt is more effective, allergic to sulfonamides should be avoided, renal function of the person with caution.
Pharmacological Effect of Sulfachloropyrazine sodium.
After internal administration, it is rapidly absorbed in the digestive tract, the blood concentration reaches the peak value in 3~4h, and is rapidly excreted through the kidneys. It is mostly applied for a short period of time during the outbreak of coccidia. The peak of its anti-coccidial activity is the second generation of schizonts of coccidia, that is,the fourth day after infection.
It also has a certain effect on the generation of schizonts. The action characteristics of poultry coccidia are similar to those of sulfa quinoline, and it has stronger antibacterial effect on Bartonella and Salmonella, without affecting the body's immunity to coccidia, and it is ineffective against coccidia in the sexual cycle stage.
Production methods of Bulk Sulfachloropyrazine sodium Powder.
1) Preparation of sulfachloropyrazine: 25 g (0.145 mole) of sulfanilamide and 21.6 g (0.145 mole) of 2,3-dichloropyrazine were added to a three-necked vial and dissolved in 60 ml of toluene. 22.4 g of potassium carbonate (0.16 mole) and 2 g of tetrabutylammonium bromide (0.006 mole) were added and heated to 110~115°C. The reaction was held at 110~115°C and refluxed for 10 hours while the water was partitioned out.
At the end of the reaction, the toluene was recovered under reduced pressure until the reaction temperature reached 115 ℃, the recovery of toluene was finished, the reaction solution was cooled down to 78~82 ℃, 40 g of drinking water was added, the pH was adjusted with hydrochloric acid at 4.5~5.0, the temperature was cooled down to 25 ℃, it was filtered and washed with water, and 35.5 g of sulfachloropyrazine was obtained with a yield of 86%.
(2) Preparation of sodium sulfachloropyrazine: in a three-necked flask, add 30 g (0.145 mol) sulfachloropyrazine and 120 g of purified water, warm up to 60 ℃, add 40% of sodium hydroxide solution 16 g, warmed up to 70 ℃, add 0.5 g of activated carbon, at 75 ℃ holding decolourisation for 30 minutes, filtration of activated carbon, the filtrate is cooled down to 0 ℃, filtration of the product to get sodium sulfachloropyrazine sodium monohydrate crude product 31.5 g, 92% yield
(3) Refined sulfachloropyrazine sodium: 50 grams of sulfachloropyrazine sodium crude with 135 ml of methanol -dichloromethane solvent (2: 1 w / w) heating to dissolve, add 2 grams of activated carbon, heating to reflux,decolourisation for 1 hour. The filtrate was filtered while hot, and the filtrate was cooled to below 5°C. 45 g of Sulfachloropyrazine sodium bouquet was obtained by filtration in 90% yield. Detected by HPLC, the purity is more than 99.5%.
Why choose us?
HRK Factory
About Shipping
Pharmaceutical Intermediate manufacturers
©2022 Xi'an Henrikang Biotech Co., Ltd.,
Home
E-mail
Booking