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Selamectin of Usage and Synthesis.

The mechanism of action of seramectin is the same as that of other abamectin drugs. On the one hand, seramectin can act as an agonist of GABA to trigger the release of presynaptic GABA, thus causing the increase of membrane permeability to Cl¯; on the other hand, the drug can open the chloride ion channels controlled by glutamate, resulting in the increase of Cl¯ permeability leading to membrane potential hyperpolarization. Thus blocking the transmission of nerve signals, causing rapid, fatal and non-spastic neuromuscular paralysis and death. Since flukes and tapeworms do not have GABA neurotransmitter and glutamate-controlled Cl¯ channels, these drugs have no repellent effect on them. The drug binding site of invertebrates is in peripheral tissues, while the drug binding site of mammals is in the central nervous system. Due to the effect of the blood-brain barrier, such drugs rarely enter the brain tissue, so such drugs are safe for most mammals.

Uses of Selamectin.

The safety of seramectin has been greatly improved, and both oral and injection have good effects. Seramectin is a kind of in vivo and in vitro insecticide mainly for adult fleas, filaria and mange in pet cats and dogs.

Preparation of Selamectin.

Product method of Bulk Selamectin Powder.

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